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Titolo:
Gene therapy in transplantation
Autore:
Giannoukakis, N; Thomson, AW; Robbins, PD;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Biochem, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Dept Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 pt Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh, Sch Med, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 at Inst, Pittsburgh, PA 15261 USA
Titolo Testata:
GENE THERAPY
fascicolo: 9, volume: 6, anno: 1999,
pagine: 1499 - 1511
SICI:
0969-7128(199909)6:9<1499:GTIT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; INTERCELLULAR-ADHESION MOLECULE-1; PANCREATIC-ISLET ALLOGRAFTS; HEPATIC ISCHEMIA/REPERFUSION INJURY; MAJOR HISTOCOMPATIBILITY COMPLEX; FUNCTION-ASSOCIATED ANTIGEN-1; SINUSOIDAL ENDOTHELIAL-CELLS; MESSENGER-RNA EXPRESSION; FAS-MEDIATED APOPTOSIS; TUMOR NECROSIS FACTOR;
Keywords:
transplantation; gene therapy tolerance; allograft; rejection;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
171
Recensione:
Indirizzi per estratti:
Indirizzo: Robbins, PD Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 tsburgh, PA 15261 USA
Citazione:
N. Giannoukakis et al., "Gene therapy in transplantation", GENE THER, 6(9), 1999, pp. 1499-1511

Abstract

Facilitation of solid organ and cell transplantation depends on metabolic and immunologic factors that can be manipulated ex vivo and in vivo using gene transfer technology. Vectors have been developed which can optimally transfer relevant genes to various tissues and organs, interventions aimed atpromoting tissue preservation before transplantation, prevention of oxidative stress and immunological rejection have recently become attractive options using viral and nonviral gene delivery vehicles. Further understanding of the mechanisms involved in tolerance induction as well as the facilitation of xenogeneic engraftment have made possible a variety of avenues that can be exploited using gene transfer technology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:12:29