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Titolo:
Cerebellar involvement in Pick's disease: Affliction of mossy fibers, monodendritic brush cells, and dentate projection neurons
Autore:
Braak, E; Arai, K; Braak, S;
Indirizzi:
Univ Frankfurt, Dept Anat, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 nat, D-60590 Frankfurt, Germany
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 159, anno: 1999,
pagine: 153 - 163
SICI:
0014-4886(199909)159:1<153:CIIPDA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERPHOSPHORYLATED TAU-PROTEIN; MICROTUBULE-ASSOCIATED PROTEIN; SHARE ANTIGENIC DETERMINANTS; NEUROFIBRILLARY TANGLES; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; LEWY BODIES; OLIVOPONTOCEREBELLAR ATROPHY; CORTICOBASAL DEGENERATION; MONOCLONAL-ANTIBODIES;
Keywords:
Pick's disease; cerebellar cortex; dentate nucleus; cerebellar mossy fibers; monodendritic brush cells; neuronal cytoskeleton; tauopathies; tau protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Braak, E Univ Frankfurt, Dept Anat, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590 any
Citazione:
E. Braak et al., "Cerebellar involvement in Pick's disease: Affliction of mossy fibers, monodendritic brush cells, and dentate projection neurons", EXP NEUROL, 159(1), 1999, pp. 153-163

Abstract

Pick's disease chiefly is characterized by progressive degeneration of specific telencephalic cortical areas and associated subcortical nuclei, Components of the cerebellum also are affected. Immunoreactions for abnormally hyperphosphorylated tau protein, indicating the development of cytoskeletal anomalies in a few susceptible neuroectodermal cell types, permit visualization and identification of the pathology. Initially accumulations of nonargyrophilic material appear in the perikarya and cellular processes of susceptible nerve cells. In some neuronal types, the abnormal deposits are transformed into more condensed inclusions, so-called Pick bodies in perikarya and Pick neurites in cellular processes, some of which become argyrophilic inthe course of the disease. This study employs silver techniques and immunoreactions to draw attention to Pick's disease-associated lesions in the cerebellar cortex and cerebellar nuclei. Immunoreactive rosettes, which correspond to the terminal synaptic boutons of mossy fibers, frequently are encountered in the cerebellar granule cell layer. Some cases of Pick's disease also exhibit afflicted monodendritic brush cells in this layer. Single immunopositive Purkinje cells occasionally are seen as well. The brunt of the alterations is borne by cerebellar subdivisions receiving dense input from the telencephalic cortex through the pontocerebellar pathway (neocerebellum). The dentate nucleus shows immunoreactive axons with numerous varicose thickenings which remain confined to the reaches of this band-like nuclear grayand probably represent collaterals of altered mossy fibers. A large numberof the dentate projection cells also contain the abnormal material in the perikarya, as well as in all of the neuronal processes. Many of these cellsdevelop spherical nonargyrophilic condensations of this material. Output of the neocerebellum is conveyed to extended territories of the telencephalic cortex via the dentate nucleus and thalamus. Therefore, all of the cerebellar territories which receive major input from and generate output chieflyto the telencephalic cortex (pontocerebellum or neocerebellum) are notablyafflicted in Pick's disease. Other subdivisions with preponderant input from the spinal cord and/or other noncortical sources remain intact or else are only minimally involved. It is concluded that the pattern of cerebellar involvement reflects Pick's disease-associated neocortical destruction. (C)1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 09:56:14