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Titolo:
DIAGNOSTIC AND PROGNOSTIC MARKERS FOR HUMAN PROSTATE-CANCER
Autore:
GAO X; PORTER AT; GRIGNON DJ; PONTES JE; HONN KV;
Indirizzi:
WAYNE STATE UNIV,SCH MED,DEPT RADIAT ONCOL,DIV CANC BIOL,431 CHEM BLDG DETROIT MI 48202 WAYNE STATE UNIV,SCH MED,DEPT RADIAT ONCOL,DIV CANC BIOL DETROIT MI 48202 WAYNE STATE UNIV,DEPT INTERNAL MED DETROIT MI 48202 HARPER GRACE HOSP,GERSHENSON RADIAT ONCOL CTR,DETROIT MED CTR DETROITMI 00000 WAYNE STATE UNIV,DEPT PATHOL DETROIT MI 48202 WAYNE STATE UNIV,DEPT UROL DETROIT MI 00000 WAYNE STATE UNIV,DEPT CHEM DETROIT MI 48202
Titolo Testata:
The Prostate
fascicolo: 4, volume: 31, anno: 1997,
pagine: 264 - 281
SICI:
0270-4137(1997)31:4<264:DAPMFH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOCARCINOMA CELL-LINE; POLYMERASE CHAIN-REACTION; ANTIGEN MESSENGER-RNA; IMMUNOGLOBULIN BINDING-FACTOR; PREDICT PATHOLOGICAL STAGE; NONPOLYPOSIS COLON-CANCER; INHIBIN-LIKE PEPTIDE; HUMAN SEMINAL PLASMA; MOLECULE E-CADHERIN; GROUP PROTEIN I(Y);
Keywords:
PROSTATIC CARCINOMA; TUMOR MARKERS; DIAGNOSIS; PROGNOSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
192
Recensione:
Indirizzi per estratti:
Citazione:
X. Gao et al., "DIAGNOSTIC AND PROGNOSTIC MARKERS FOR HUMAN PROSTATE-CANCER", The Prostate, 31(4), 1997, pp. 264-281

Abstract

BACKGROUND. The incidence and mortality of prostate cancer are increasing at alarming rates, partially due to an aging population. Early detection of prostate cancer, using clinically sensitive procedures and/or tumor markers (e.g., prostate-specific antigen [PSA]), is of prime importance. However, the choice of therapeutic interventions for prostate cancer at the time of diagnosis is largely dependent on clinical and pathologic staging and prediction of the degree of agressiveness ofthe disease. Clinically applicable prognostic markers are urgently needed to assist in the selection of optimal therapy. METHODS. Literature review of the potential diagnostic and prognostic markers for human prostate cancer. RESULTS. Well-established tissue prognostic indicators, including histologic grade, margin positivity, pathologic stage, intraglandular tumor extent, and DNA ploidy, are not reviewed in this paper. Recently, a number of novel markers have been identified. In thispaper, we begin with a discussion of a number of well-established as well as investigational diagnostic markers and then focus on evaluation of prognostic markers. Diagnostic markers that have prognostic valueand investigational prognostic markers are also discussed. CONCLUSIONS. Currently, only PSA is utilized for early diagnosis and monitoring of prostate cancer. A number of potential prognostic markers warrant further investigation. Multimarker analysis is implicated. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:42:59