Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Biochemical liver abnormalities in Turner's syndrome
Autore:
Albareda, MM; Gallego, A; Enriquez, J; Rodriguez, JL; Webb, SM;
Indirizzi:
UAB, Hosp St Pau, Dept Endocrinol, Barcelona, Spain UAB Barcelona SpainUAB, Hosp St Pau, Dept Endocrinol, Barcelona, Spain
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 9, volume: 11, anno: 1999,
pagine: 1037 - 1039
SICI:
0954-691X(199909)11:9<1037:BLAITS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Keywords:
autoimmune hepatitis; liver cholestasis; oestrogen therapy; Turner's syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Webb, SM UAB, Hosp St Pau, Dept Endocrinol, Av St Antoni M Claret 167, Barcelona, Spain UAB Av St Antoni M Claret 167 Barcelona Spain Barcelona, Spain
Citazione:
M.M. Albareda et al., "Biochemical liver abnormalities in Turner's syndrome", EUR J GASTR, 11(9), 1999, pp. 1037-1039

Abstract

Background Turner's syndrome is a chromosomal abnormality (45X0) which maybe associated with various autoimmune disorders and disease conditions; however, association with liver pathology has rarely been reported. Objectives The aim of this work was to assess liver function abnormalitiesin a group of adult patients with Turner's syndrome,Design and methods Liver function tests were performed in 16 women with Turner's syndrome all of whom had been previously treated with oestrogens, Patients with liver abnormalities were further studied with hepatic ultrasonography, serological markers of viral hepatitis and autoantibody determinations,Results Seven women (43.7%) presented with asymptomatic liver cholestasis;these patients were older than those with normal biochemical values (33.4 /- 5.2 vs 24.7 +/- 5.7 years, P< 0.05). Liver function abnormalities appeared 7.8 +/- 4.9 years after starting oestrogen therapy; however, no improvement of liver function was observed 20 +/- 17.7 months after stopping treatment. All of these women were anti-HCV and HBsAg negative, and autoimmune hepatitis was ruled out in all cases. Liver ultrasound only disclosed homogeneous liver enlargement in one case and cholelithiasis without bile duct abnormalities in another, Four patients underwent a percutaneous liver biopsyof which two were normal and two showed minimal non-specific changes. Conclusions The incidence of biochemical liver cholestasis in this group of patients with Turner's syndrome is high. Oestrogen therapy and autoimmunedisorders do not seem to be the responsible causes. It appears that this is a benign condition which does not seem to reflect any substantial liver dysfunction. The aetiology remains uncertain. fur J Gastroenterol Hepatol 11:1037-1039 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:07:38