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Titolo:
Glutamate toxicity induced degeneration of outer hair cells with a temporal increase of nitric oxide production in the guinea pig cochlea
Autore:
Sunami, K; Yamane, H; Nakagawa, T; Takayama, M; Konishi, K;
Indirizzi:
Osaka City Univ, Sch Med, Dept Otorhinolaryngol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 ngol, Abeno Ku, Osaka 5458585, Japan Yodogawa Christian Hosp, Dept Otorhinolaryngol, Osaka, Japan Yodogawa Christian Hosp Osaka Japan Dept Otorhinolaryngol, Osaka, Japan
Titolo Testata:
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
fascicolo: 7, volume: 256, anno: 1999,
pagine: 323 - 329
SICI:
0937-4477(199908)256:7<323:GTIDOO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NADPH DIAPHORASE; IN-VITRO; SYNTHASE; BRAIN; EXCITOTOXICITY; NEUROTOXICITY; OTOTOXICITY; INHIBITION; CULTURES; KAINATE;
Keywords:
cochlear hair cells; glutamate toxicity; nitric oxide synthase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sunami, K Osaka City Univ, Sch Med, Dept Otorhinolaryngol, Abeno Ku, 1-5-7Asahi Machi, Osaka 5458585, Japan Osaka City Univ 1-5-7 Asahi Machi OsakaJapan 5458585 85, Japan
Citazione:
K. Sunami et al., "Glutamate toxicity induced degeneration of outer hair cells with a temporal increase of nitric oxide production in the guinea pig cochlea", EUR ARCH OT, 256(7), 1999, pp. 323-329

Abstract

The aim of this study was to examine the roles of glutamate (GLU) toxicityand involvement of nitric oxide (NO) in the pathogenesis of cochlear degeneration. We examined guinea pig cochleae following chronic exposure to GLU. Trypan blue extrusion and transmission electron microscopy were performed to evaluate degeneration in the organ of Corti. In parallel, nitric oxide synthase (NOS) activity was demonstrated by histochemical staining of NADPH diapholase. GLU treatment caused time-dependent degeneration of outer hair cells (OHCs) in conjunction with a temporal increase of NOS activity in theorgan of Corti. This suggests that GLU may be involved in OHC degenerationunder toxic conditions, with NO production possibly playing a role in thisprocess.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:43:14