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Titolo:
Deficient antibody-dependent cellular cytotoxicity against human immunodeficiency virus (HIV)-expressing target cells in perinatal HIV infection
Autore:
Ziegner, U; Campbell, D; Weinhold, K; Frank, I; Rutstein, R; Starr, SE;
Indirizzi:
Childrens Hosp Philadelphia, Div Allergy Immunol & Infect Dis, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA Hosp Univ Penn, Div Infect Dis, Philadelphia, PA 19104 USA Hosp Univ PennPhiladelphia PA USA 19104 Dis, Philadelphia, PA 19104 USA Duke Univ, Dept Surg, Durham, NC USA Duke Univ Durham NC USADuke Univ, Dept Surg, Durham, NC USA
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 5, volume: 6, anno: 1999,
pagine: 718 - 724
SICI:
1071-412X(199909)6:5<718:DACCAH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFERENT CLINICAL STAGES; CIRCULATING IMMUNE-COMPLEXES; MEDIATED CYTO-TOXICITY; AIDS-RELATED COMPLEX; NATURAL-KILLER; SEROPOSITIVE INDIVIDUALS; EFFECTOR-CELLS; TYPE-1 INFECTION; NK-CELLS; HTLV-III;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Ziegner, U Univ Calif Los Angeles, Childrens Hosp, Div Allergy & Immunol, MDCC, RM 22-387, Los Angeles, CA 90095 USA Univ Calif Los Angeles RM 22-387Los Angeles CA USA 90095 5 USA
Citazione:
U. Ziegner et al., "Deficient antibody-dependent cellular cytotoxicity against human immunodeficiency virus (HIV)-expressing target cells in perinatal HIV infection", CL DIAG LAB, 6(5), 1999, pp. 718-724

Abstract

Peripheral blood mouonuclear cells (PBMC) of human immunodeficiency virus (HIV)-infected children, age-matched HIV-seronegative controls, and HIV-infected asymptomatic and symptomatic adults were compared for their ability to mediate antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell-mediated cytotoxicity against target cells expressing HIV or herpes simplex virus (HSV) antigens, Target cells consisted of CD4 lymphocytes purified from PBMC of HIV-seronegative adults and incubated with the IIIBstrain of HIV, HUT78 cells chronically infected with IIIB, and HSV-infected human fibroblasts. PBMC of asymptomatic HIV-infected adults were generally able to lyse CD4 cells expressing HIV antigens. Direct correlation was found between the magnitude of lysis and absolute CD4 cell counts in these individuals. In contrast to these results, PBMC from HIV-infected children were generally unable to lyse IIIB-expressing CD4 cells, regardless of the children's clinical status, age, or absolute CD4 cell counts. Cells from HIV-seronegative adults and children did not directly lyse these target cells either but, in contrast to cells of HIV-seropositive children, were able to mediate cell lysis when serum from an HIV-seropositive adult was added. However, effector cells from these HIV-infected children were able to mediate both ADCC against HSV-infected fibroblasts and NK cell-mediated cytotoxicity against DID-infected HUT78 cells. Reduced ability of PBMC from verticallyHIV-infected children to mediate ADCC against HIV antigen expressing CD4 cells may contribute to rapid progression to AIDS.

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Documento generato il 09/07/20 alle ore 20:28:25