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Titolo:
Detection of Borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay
Autore:
Yamaguchi, K; Sawada, T; Naraki, T; Igata-Yi, R; Shiraki, H; Horii, Y; Ishii, T; Ikeda, K; Asou, N; Okabe, H; Mochizuki, M; Takahashi, K; Yamada, S; Kubo, K; Yashiki, S; Waltrip, RW; Carbone, KM;
Indirizzi:
Kumamoto Univ, Sch Med, Blood Transfus Serv, Ikeda, Kumamoto 860, Japan Kumamoto Univ Ikeda Kumamoto Japan 860 s Serv, Ikeda, Kumamoto 860, Japan Eisai Tsukuba Res Labs, Div Diagnost, Tsukuba, Ibaraki, Japan Eisai Tsukuba Res Labs Tsukuba Ibaraki Japan st, Tsukuba, Ibaraki, Japan Kumamoto City Publ Hlth Off, Kumamoto, Japan Kumamoto City Publ Hlth Off Kumamoto Japan bl Hlth Off, Kumamoto, Japan Fukuoaka Red Cross Blood Ctr, Fukuoka, Japan Fukuoaka Red Cross Blood CtrFukuoka Japan ss Blood Ctr, Fukuoka, Japan Miyazaki Univ, Fac Agr, Dept Vet Internal Med, Miyazaki 88921, Japan Miyazaki Univ Miyazaki Japan 88921 t Internal Med, Miyazaki 88921, Japan Tokyo Inst Psychiat, Dept Ultrastruct & Histochem, Tokyo, Japan Tokyo InstPsychiat Tokyo Japan t Ultrastruct & Histochem, Tokyo, Japan Kurume Univ, Sch Med, Dept Ophthalmol, Kurume, Fukuoka 830, Japan Kurume Univ Kurume Fukuoka Japan 830 hthalmol, Kurume, Fukuoka 830, Japan Fukushima Med Coll, Dept Microbiol, Fukushima, Japan Fukushima Med Coll Fukushima Japan ll, Dept Microbiol, Fukushima, Japan Kyushu Univ, Sch Med, Dept Psychiat Med, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 Med, Dept Psychiat Med, Fukuoka 812, Japan Kagoshima Univ, Sch Med, Dept Neuropsychiat & Virol, Kagoshima 890, Japan Kagoshima Univ Kagoshima Japan 890 sychiat & Virol, Kagoshima 890, Japan Univ Mississippi, Med Ctr, Dept Psychiat, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 ept Psychiat, Jackson, MS 39216 USA US FDA, Div Viral Prod, Washington, DC 20204 USA US FDA Washington DC USA20204 , Div Viral Prod, Washington, DC 20204 USA
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 5, volume: 6, anno: 1999,
pagine: 696 - 700
SICI:
1071-412X(199909)6:5<696:DOBDVA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD MONONUCLEAR; RNA; CELLS; SCHIZOPHRENIA; INFECTION; BDV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, K Kumamoto Univ, Sch Med, Blood Transfus Serv, Honjo 1-1-1, Ikeda, Kumamoto 860, Japan Kumamoto Univ Honjo 1-1-1 Ikeda Kumamoto Japan 860 860, Japan
Citazione:
K. Yamaguchi et al., "Detection of Borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay", CL DIAG LAB, 6(5), 1999, pp. 696-700

Abstract

The prevalence of Borna disease virus (BDV)-specific antibodies among patients with psychiatric disorders and healthy individuals has varied in several reports using several different serological assay methods. A reliable and specific method for anti-BDV antibodies needs to be developed to clarify the pathological significance of BDV infections in humans. We developed a new electrochemiluminescence immunoassay (ECLIA) for the antibody to BDV that uses two recombinant proteins of BDV, p40 and p24 (full length). Using this ECLIA, we examined 3,476 serum samples from humans with various diseasesand 917 sera from blood donors in Japan for the presence of anti-BDV antibodies. By ECLIA, 26 (3.08%) of 845 schizophrenia patients and 9 (3.59%) of 251 patients with mood disorders were seropositive for BDV. Among 323 patients with other psychiatric diseases, 114 with neurological diseases, 75 with chronic fatigue syndrome, 85 human immunodeficiency virus-infected patients, 50 with autoimmune diseases including rheumatoid arthritis and systemiclupus erythematosis and 17 with leprosy, there was no positive case exceptone case each with alcohol addiction, AIDS, and dementia. Although 19 (1.36%) of 1,393 patients with various ocular diseases, 10 (1.09%) of 917 blooddonors, and 3 (4.55%) of 66 multitransfused patients were seropositive forBDV-specific antigen, high levels of seroprevalence in schizophrenia patients and young patients (16 to 59 years old) with mood disorders were statistically significant. The immunoreactivity of seropositive sera could be verified for specificity by blocking with soluble p40 and/or p24 recombinant protein. Anti-p24 antibody was more frequent than p40 antibody in most cases, and in some psychotic patients antibody profiles showed only p40 antibody. Although serum positive for both p40 and p24 antibodies was not found in this study, the p40 ECLIA count in schizophrenia patients was higher than that of blood donors. Furthermore, we examined 90 sera from Japanese feral horses. Antibody profiles of control human samples are similar to that of naturally BDV-infected feral horses. We concluded that BDV infection was associated in some way with psychiatric disorders.

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Documento generato il 20/09/20 alle ore 00:22:52