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Titolo:
Cancer anorexia-cachexia syndrome: Are neuropeptides the key?
Autore:
Inui, A;
Indirizzi:
Kobe Univ, Sch Med, Dept Internal Med 2, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 2, Chuo Ku, Kobe, Hyogo 6500017, Japan
Titolo Testata:
CANCER RESEARCH
fascicolo: 18, volume: 59, anno: 1999,
pagine: 4493 - 4501
SICI:
0008-5472(19990915)59:18<4493:CASANT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; TUMOR-BEARING RATS; MELANOCYTE-STIMULATING-HORMONE; MELANIN-CONCENTRATING HORMONE; NECROSIS-FACTOR-ALPHA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CILIARY NEUROTROPIC FACTOR; AGOUTI OBESITY SYNDROME; GLUCAGON-LIKE PEPTIDE-1; CENTRAL-NERVOUS-SYSTEM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
154
Recensione:
Indirizzi per estratti:
Indirizzo: Inui, A Kobe Univ, Sch Med, Dept Internal Med 2, Chuo Ku, Kusunoki Cho, Kobe, Hyogo 6500017, Japan Kobe Univ Kusunoki Cho Kobe Hyogo Japan 6500017 ogo 6500017, Japan
Citazione:
A. Inui, "Cancer anorexia-cachexia syndrome: Are neuropeptides the key?", CANCER RES, 59(18), 1999, pp. 4493-4501

Abstract

Progressive wasting is common in many types of cancer and is one of the most important factors leading to early death in cancer patients. Weight lossis a potent stimulus to food intake in normal humans and animals. The persistence of anorexia in cancer patients, therefore, implies a failure of this adaptive feeding response, although the weight loss in the patients differs from that found in simple starvation. Tremendous progress has been made in the last 5 years with regard to the regulation of feeding and body weight. It has been demonstrated that leptin, a hormone secreted by adipose tissue, is an integral component of the homeostatic loop of body weight regulation Leptin acts to control food intake and energy expenditure via neuropeptidergic effector molecules within the hypothalamus, Complex interactions among the nervous, endocrine, and immune systems affect the loop and induce behavioral and metabolic responses. A number of cytokines, including tumor necrosis factor-ru, interleukins 1 and 6, IFN-gamma, leukemia inhibitory factor, and ciliary neurotrophic factor have been proposed as mediators of thecachectic process. Cytokines may play a pivotal role in long-term inhibition of feeding by mimicking the hypothalamic effect of excessive negative feedback signaling from leptin, This could be done by persistent stimulation of anorexigenic neuropeptides such as corticotropin-releasing factor, as well as by inhibition of the neuropeptide Y orexigenic network that consists of opioid peptides and galanin, in addition to the newly identified melanin-concentrating hormone, orexin, and agouti-related peptide. Information is being gathered, although it is still insufficient, on such abnormalities inthe hypothalamic neuropeptide circuitry in tumor-bearing animals that coincide with the development of anorexia and cachexia, Characterization of thefeeding-associated gene products have revealed new biochemical pathways and molecular targets for pharmacological intervention that will likely lead to new treatments. Although therapeutic intervention using neuropeptide agonists/antagonists is now directed at obesity treatment, it may also have aneffect on treating cancer anorexia-cachexia, especially when combined withother agents that have effects on muscle and protein breakdown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:32:17