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Titolo:
Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide
Autore:
Cartwright, JE; Holden, DP; Whitley, GS;
Indirizzi:
St George Hosp, Sch Med, Dept Biochem, London SW17 0RE, England St George Hosp London England SW17 0RE Biochem, London SW17 0RE, England
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 128, anno: 1999,
pagine: 181 - 189
SICI:
0007-1188(199909)128:1<181:HGFRHT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED ENDOTHELIAL-CELLS; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; PLASMA-CONCENTRATIONS; NORMAL-PREGNANCY; HUMAN PLACENTA; PREECLAMPSIA; SYNTHASE; MIGRATION; ADHESION;
Keywords:
trophoblast; hepatocyte growth factor; nitric oxide; motility; invasion; placenta; pre-eclampsia; inducible nitric oxide synthase; constitutive nitric oxide synthase; asymmetric dimethylarginine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Cartwright, JE St George Hosp, Sch Med, Dept Biochem, Cranmer Terrace, London SW17 0RE, England St George Hosp Cranmer Terrace London England SW17 0RE and
Citazione:
J.E. Cartwright et al., "Hepatocyte growth factor regulates human trophoblast motility and invasion: a role for nitric oxide", BR J PHARM, 128(1), 1999, pp. 181-189

Abstract

1 The expression of hepatocyte growth factor (HGF) is essential for normalplacental development although its function is unknown. In this study we examined the effect of HGF on trophoblast cell motility and invasion of fibrin gels and investigated the possible role of nitric oxide (NO) in this process.2 The human extravillous trophoblast cell line SGHPL-4 express both the constitutive and inducible isoforms of nitric oxide synthase (NOS).3 HGF significantly stimulates cell motility in monolayer culture, the invasion of fibrin gels and the production of guanosine 3':5'-cyclic monophosphate (cyclic GMP).4 Invasion, motility and cyclic GMP production were inhibited by N-g-monomethyl-L-arginine (L-NMMA).5 Cell motility was also significantly inhibited by the inducible NOS specific inhibitor 1400 W.6 Neither 8 Br-cyclic GMP nor the NO donor spermine-NO had any significanteffect on basal trophoblast cell motility. 7 The data presented in this study demonstrate a direct effect of trophoblast-derived NO synthesis on trophoblast cell function and support the idea that HGF is involved in the regulation of trophoblast invasion through mechanisms that involve the production of NO. However neither exogenous NO nor activation of cyclic GMP-dependent pathways alone are sufficient to stimulate trophoblast cell motility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:26:35