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Titolo:
Inhibitory effect of nociceptin on [H-3]-5-HT release from rat cerebral cortex slices
Autore:
Siniscalchi, A; Rodi, D; Beani, L; Bianchi, C;
Indirizzi:
Univ Ferrara, Dept Clin & Expt Med, Pharmacol Sect, I-44100 Ferrara, ItalyUniv Ferrara Ferrara Italy I-44100 harmacol Sect, I-44100 Ferrara, Italy
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 128, anno: 1999,
pagine: 119 - 123
SICI:
0007-1188(199909)128:1<119:IEONO[>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORPHAN OPIOID RECEPTOR; ORL(1) RECEPTOR; FQ; ANTAGONIST;
Keywords:
nociceptin; ORL1 receptors; 5-HT release; cerebral cortex; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Beani, L Univ Ferrara, Dept Clin & Expt Med, Pharmacol Sect, Via Fossato Mortara 17-19, I-44100 Ferrara, Italy Univ Ferrara Via Fossato Mortara 17-19Ferrara Italy I-44100 aly
Citazione:
A. Siniscalchi et al., "Inhibitory effect of nociceptin on [H-3]-5-HT release from rat cerebral cortex slices", BR J PHARM, 128(1), 1999, pp. 119-123

Abstract

1 The effect of nociceptin (NC) on S-hydroxytryptamine (5-HT) release was studied in rat cerebral cortex slices preincubated with [H-3]-5-HT and electrically stimulated (3 Hz for 2 min) at the 45th (St(1)) and the 75th (St(2)) min of superfusion.2 NC (0.1-3 mu M), present in the medium from the 70th min onward, concentration-dependently reduced electrically evoked [H-3]-5-HT efflux (pEC(50) =6.54, E-max -54%). The inhibition was not antagonized by naloxone (1 mu M)ruling out the involvement of opioid receptors.3 Phe(1)psi(CH2-NH2)Gly(2)]NC(1-13)NH2, which acts as an opioid-like receptor (ORL1) antagonist at the peripheral level, behaved as a partial agonistin cerebral cortex slices i.e. it inhibited [H-3]-5-HT efflux when added before St(2), however, when present in the medium throughout the whole experiment, [Phe(1)psi(CH2-NH2)Gly(2)]NC(1-13)NH2 prevented the action of NC added at the 70th min.4 The non-selective ORL1 receptor antagonist, naloxone benzoylhydrazone (3mu M), in the presence of 10 mu M naloxone, did not modify the St(2)/St(1), ratio but completely abolished the NC effect.5 These findings demonstrate that NC inhibits 5-HT release from rat cerebral cortex slices via ORL1, receptors, suggesting its involvement in centralprocesses :mediated by 5-HT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:08:31