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Titolo:
Locus coeruleus neuronal activity and noradrenaline availability in the frontal cortex of rats chronically treated with imipramine effect of alpha(2)-adrenoceptor blockade
Autore:
Linner, L; Arborelius, L; Nomikos, GG; Bertilsson, L; Svensson, TH;
Indirizzi:
Karolinska Inst, Dept Physiol & Pharmacol, Sect Neuropsychopharmacol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 acol, S-17177 Stockholm, Sweden Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA Emory Univ Atlanta GA USA ed, Dept Psychiat & Behav Sci, Atlanta, GA USA Eli Lilly & Co, Lilly Corp Ctr, Neurosci Res, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 Res, Indianapolis, IN 46285 USA Huddinge Univ Hosp, Karolinska Inst, Dept Med Lab Sci & Technol, Div Clin Pharmacol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 col, S-14186 Huddinge, Sweden
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 46, anno: 1999,
pagine: 766 - 774
SICI:
0006-3223(19990915)46:6<766:LCNAAN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN NORADRENERGIC NEURONS; TRICYCLIC ANTIDEPRESSANTS; IN-VIVO; CITALOPRAM; DESIPRAMINE; RELEASE; RECEPTORS; INCREASE; INVIVO; DRUGS;
Keywords:
noradrenaline; tricyclic antidepressants; alpha(2)-adrenoceptors; electrophysiology; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Svensson, TH Karolinska Inst, Dept Physiol & Pharmacol, Sect Neuropsychopharmacol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Stockholm, Sweden
Citazione:
L. Linner et al., "Locus coeruleus neuronal activity and noradrenaline availability in the frontal cortex of rats chronically treated with imipramine effect of alpha(2)-adrenoceptor blockade", BIOL PSYCHI, 46(6), 1999, pp. 766-774

Abstract

Background: previous studies indicate a reduced feed-back inhibition of brain noradrenaline (NA) neurons in the locus coeruleus (LC) during chronic administration of antidepressants which inhibit the NA reuptake mechanism due to functional downregulation of somatodendritic alpha(2)-adrenoceptors inthe LC. Therefore, we have here studied the LC neuronal responsiveness to administration of the alpha(2)-adpenoceptor antagonist idazoxan (IDA) afterboth short-term and long-term imipramine (IMI) administration. Methods: Rats were treated for different periods with systemic IMI. In these rats, basal activity of central noradrenergic function and the effect ofIDA was assessed by means of extracellular single-cell recording from LC neurons and in vivo microdialysis of extracellular NA levels in the frontal cortex (FC),Results: The average firing rate of LC neurons was significantly reduced in rats by short-term IMI treatment compared with long-term treatment. The output of NA in the FC of all IMI-treated animals was significantly increased compared with saline-treated rats. Moreover, the enhancing effect of IDA on both the firing rate of LC neurons and the cortical NA output was largerin rats after long-term treatment with IMI than after shout-term administration. Conclusions: Our results clearly support the nation of development of functional downregulation of alpha(2)-autoreceptors on LC neurons during chronic administration of NA reuptake inhibiting antidepressants. Moreover, the data suggest that addition of alpha(2)-adrenoceptor antagonists may augment the clinical effect of such drugs in major depression. (C) 1999 Society of Biological Psychiatry.

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Documento generato il 01/10/20 alle ore 07:42:49