Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tolerance to the antinociceptive effect of morphine microinjections into the ventral but not lateral-dorsal periaqueductal gray of the rat
Autore:
Tortorici, V; Robbins, CS; Morgan, MM;
Indirizzi:
Washington State Univ, Dept Psychol, Vancouver, WA 98686 USA Washington State Univ Vancouver WA USA 98686 hol, Vancouver, WA 98686 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 4, volume: 113, anno: 1999,
pagine: 833 - 839
SICI:
0735-7044(199908)113:4<833:TTTAEO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATION-PRODUCED ANALGESIA; ROSTRAL VENTROMEDIAL MEDULLA; CROSS-TOLERANCE; INTRATHECAL MORPHINE; OFF-CELLS; NEURONS; DEPENDENCE; MK-801; MATTER; GABA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Tortorici, V Washington State Univ, Dept Psychol, 14204 NE Salmon Creek Ave, Vancouver,WA 98686 USA Washington State Univ 14204 NE Salmon Creek Ave Vancouver WA USA 98686
Citazione:
V. Tortorici et al., "Tolerance to the antinociceptive effect of morphine microinjections into the ventral but not lateral-dorsal periaqueductal gray of the rat", BEHAV NEURO, 113(4), 1999, pp. 833-839

Abstract

Tolerance to the antinociceptive effect of morphine is mediated at least in part by morphine's action within the periaqueductal gray (PAG). The objective of the present study was to determine whether both ventral and lateral-dorsal PAG regions contribute to the development of tolerance. It was found that the antinociceptive efficacy of microinjecting morphine (5 mu g/0.4 mu l) into the ventral but not the lateral-dorsal PAG diminished with successive injections. Control experiments indicated that this decrease was caused by tolerance to morphine and was not a result of cell death caused by repeated microinjections or habituation from repeated behavioral testing. Thefinding of greater susceptibility of the ventral compared with the lateral-dorsal PAG to the development of tolerance adds to a growing literature distinguishing antinociception from these two regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:24:21