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Titolo:
Inescapable shock-induced potentiation of morphine analgesia in rats: Sites of action
Autore:
Hammack, SE; Hartley, CE; Lea, SE; Maier, SF; Watkins, LR; Sutton, LC;
Indirizzi:
Univ Colorado, Dept Psychol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 o, Dept Psychol, Boulder, CO 80309 USA Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA Univ Cent Florida Orlando FL USA 32816 ept Psychol, Orlando, FL 32816 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 4, volume: 113, anno: 1999,
pagine: 795 - 803
SICI:
0735-7044(199908)113:4<795:ISPOMA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS RAPHE MAGNUS; FREELY MOVING CATS; SEROTONIN-CONTAINING NEURONS; DORSAL RAPHE; PERIAQUEDUCTAL GRAY; BRAIN-STEM; INDUCED ANTINOCICEPTION; PAIN MODULATION; 5-HT METABOLISM; INTERFERENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Hammack, SE Univ Colorado, Dept Psychol, Campus Box 345, Boulder, CO 80309USA Univ Colorado Campus Box 345 Boulder CO USA 80309 CO 80309 USA
Citazione:
S.E. Hammack et al., "Inescapable shock-induced potentiation of morphine analgesia in rats: Sites of action", BEHAV NEURO, 113(4), 1999, pp. 795-803

Abstract

Inescapable shock (IS) enhances analgesia to systemic morphine (MOR) 24 hrlater. IS activates serotonin neurons in the dorsal raphe nucleus (DRN), rendering them hyperexcitable. These studies tested whether IS potentiates the analgesic effect of MOR microinjected in the DRN, as predicted by this hypothesis. To test site specificity, the effect of previous IS was examinedon MOR microinjected lateral to the DRN and into 2 other sites that support MOR analgesia, the nucleus raphe magnus (NRM) and spinal cord. Twenty-four hours after IS, potentiated analgesia was observed after 0.5 mu g MOR microinjected into, but not lateral to, the DRN. Potentiated analgesia was also observed after NRM (1.0 mu g) and spinal cord (3.0 mu g) MOR microinjections. These data suggest that IS-induced excitability changes within the DRNsynergize with opiates microinjected in other analgesia areas and that this potentiates the responses to opiates 24 hr after IS.

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Documento generato il 30/11/20 alle ore 03:28:42