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Titolo:
Noninvasive diagnosis of emphysema - Aerosol morphometry and aerosol bolusdispersion in comparison to HRCT
Autore:
Kohlhaufl, M; Brand, P; Rock, C; Radons, T; Scheuch, C; Meyer, T; Schulz, H; Pfeifer, KJ; Haussinger, K; Heyder, J;
Indirizzi:
Inst Inhalat Biol, GSF, Clin Res Grp Aerosols Med, Munich, Germany Inst Inhalat Biol Munich Germany Res Grp Aerosols Med, Munich, Germany Ctr Resp Med, Munich, Germany Ctr Resp Med Munich GermanyCtr Resp Med, Munich, Germany Univ Munich, Klinikum Innenstadt, Dept Radiol, D-8000 Munich, Germany UnivMunich Munich Germany D-8000 t, Dept Radiol, D-8000 Munich, Germany
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 3, volume: 160, anno: 1999,
pagine: 913 - 918
SICI:
1073-449X(199909)160:3<913:NDOE-A>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY-FUNCTION TESTS; AIRWAY MORPHOMETRY; COMPUTED-TOMOGRAPHY; CHRONIC-BRONCHITIS; HEALTHY-SUBJECTS; LUNG PATHOLOGY; CT; SMOKERS; DISEASE; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kohlhaufl, M Zentrum Pneumol & Thoraxchirurg, Fachklin Munchen Gauting, Robert Koch Allee 2, D-82131 Gauting, Germany Zentrum Pneumol & ThoraxchirurgRobert Koch Allee 2 Gauting Germany D-82131
Citazione:
M. Kohlhaufl et al., "Noninvasive diagnosis of emphysema - Aerosol morphometry and aerosol bolusdispersion in comparison to HRCT", AM J R CRIT, 160(3), 1999, pp. 913-918

Abstract

Aerosol-derived airway morphometry (ADAM) and aerosol bolus dispersion (ABD) test are altered in patients with emphysema. We examined the diagnostic power of these aerosol methods in comparison with the noninvasive "gold-standard" HRCT in 50 consecutive patients with various lung diseases. The severity of airflow limitation was mild to moderate in the group of patients without emphysema and moderate to severe in the group of patients with HRCT-confirmed emphysema (FEV1, 78 +/- 23% pred versus 53 +/- 33% pred; p < 0.001). Among all lung function parameters under consideration ADAM showed the highest sensitivity and specificity for separating patients with emphysema from those without emphysema (area under the operating characteristics curve: P-ROC 0.92), followed by ABD (P-ROC, 0.90), a marker for ventilation inhomogeneities. In patients with HRCT-confirmed macroscopic emphysema, peripheral air-space dimensions (EAD) at a relative volumetric lung depth V-pr of 0.20 measured by ADAM were 155% larger, and bolus dispersion (ABD) at a lung depth of V-p 600 ml was 53% larger than those observed in patients with other lung diseases (EAD = 0.84 +/- 0.53 mm versus 0.33 +/- 0.10 mm, p < 0.0001; ABD = 706 +/- 154 cm(3) versus 462 +/- 109 cm(3); p < 0.0001). EAD showed a significant correlation with the HRCT visual score (r = 0.78, p = 0.01). ABD showed weak significant correlations with all HRCT parameters underconsideration (visual score, pixel density, mean lung density) (r = 0.45 to 0.66; p < 0.05). ADAM and ABD are powerful tools for the noninvasive diagnosis of macroscopic emphysema.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 09:55:12