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Titolo:
N-cadherin expression in human prostate carcinoma cell lines - An epithelial-mesenchymal transformation mediating adhesion with stromal cells
Autore:
Tran, NL; Nagle, RB; Cress, AE; Heimark, RL;
Indirizzi:
Univ Arizona, Arizona Hlth Sci Ctr, Dept Surg, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Sci Ctr, Dept Surg, Tucson, AZ 85724 USA Univ Arizona, Arizona Hlth Sci Ctr, Sect Surg Res, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Ctr, Sect Surg Res, Tucson, AZ 85724 USA Univ Arizona, Arizona Hlth Sci Ctr, Canc Biol Grad Program, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Biol Grad Program, Tucson, AZ 85724 USA Univ Arizona, Arizona Hlth Sci Ctr, Dept Radiat Oncol, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Dept Radiat Oncol, Tucson, AZ 85724 USA Univ Arizona, Arizona Hlth Sci Ctr, Dept Pathol, Tucson, AZ 85724 USA UnivArizona Tucson AZ USA 85724 i Ctr, Dept Pathol, Tucson, AZ 85724 USA
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 3, volume: 155, anno: 1999,
pagine: 787 - 798
SICI:
0002-9440(199909)155:3<787:NEIHPC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-SEQUENCE; MOLECULE E-CADHERIN; ALPHA-CATENIN; HUMAN BREAST; HETEROGENEOUS EXPRESSION; INTERCELLULAR-ADHESION; CLINICAL IMPLICATIONS; DECREASED EXPRESSION; NEOPLASTIC PROSTATE; CANCER PROGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Heimark, RL Univ Arizona, Arizona Hlth Sci Ctr, Dept Surg, POB 245084,1501N Campbell,Tucson, AZ 85724 USA Univ Arizona POB 245084,1501 N Campbell Tucson AZ USA 85724 SA
Citazione:
N.L. Tran et al., "N-cadherin expression in human prostate carcinoma cell lines - An epithelial-mesenchymal transformation mediating adhesion with stromal cells", AM J PATH, 155(3), 1999, pp. 787-798

Abstract

In human prostate adenocarcinoma, an association between loss of E-cadherin, increased Gleason score, and extracapsular dissemination has been observed. Further characterization of the E-cadherin/catenin phenotype of human prostate carcinoma cell lines showed loss of E-cadherin and expression of N-cadherin in poorly differentiated prostate carcinoma cell lines (PC-3N derived from PC-3, PC-3, and JCA1). We showed that N-cadherin is concentrated at sites of cell-cell contact in PC-3N cellular extensions. N-cadherin was also expressed in prostate stromal fibroblasts both in vitro and in prostatetissue. Go-cultures of prostate stromal fibroblasts and PC-3N cells showedthe immunolocalization of N-cadherin in intercellular contacts. In addition, the isoform expression of the cadherin binding protein p120(ctn) differed in relation to the expression of E- versus N-cadherin by the prostate carcinoma cell lines. The p100 isoform was more highly expressed in E-cadherin-positive carcinoma cell lines, whereas p120 was predominantly expressed only in N-cadherin-positive prostate carcinoma cell lines and prostate stromal fibroblasts, The N-cadherin-positive carcinoma cell line, PC-3N, displayed aggressive invasion into the surface of the diaphragm muscle after intraperitoneal injection of SCID mice. The gain of N-cadherin and loss of E-cadherin by invasive prostate carcinoma cell Lines suggests a progression from an epithelial to a mesenchymal phenotype, which may allow for their interaction with surrounding stromal fibroblasts and facilitate metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:40:02