Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tripeptidyl peptidases: enzymes that count
Autore:
Tomkinson, B;
Indirizzi:
Uppsala Univ, Ctr Biomed, Dept Biochem, SE-75123 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75123 t Biochem, SE-75123 Uppsala, Sweden
Titolo Testata:
TRENDS IN BIOCHEMICAL SCIENCES
fascicolo: 9, volume: 24, anno: 1999,
pagine: 355 - 359
SICI:
0968-0004(199909)24:9<355:TPETC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEASOME; PROTEINS; AMINOPEPTIDASE; PURIFICATION; PROTEOLYSIS; DEGRADATION; INHIBITION; BESTATIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tomkinson, B Uppsala Univ, Ctr Biomed, Dept Biochem, Box 576, SE-75123 Uppsala, Sweden Uppsala Univ Box 576 Uppsala Sweden SE-75123 Uppsala, Sweden
Citazione:
B. Tomkinson, "Tripeptidyl peptidases: enzymes that count", TRENDS BIOC, 24(9), 1999, pp. 355-359

Abstract

Protein degradation is essential for the life and death of every cell. Proteins are broken down to their constitutive amino acids by a succession of peptidases, both in lysosomes and in the cytosol. Tri peptidyl-peptidases Iand II are enzymes that can 'count to three' and release N-terminal tripeptides from oligopeptides generated by different endopeptidases, The tripeptides are then degraded by other exopeptidases to release amino acids and dipeptides. Mutations in tripeptidyl-peptidase I have recently been associated with a lysosomal storage disease, late infantile neuronal ceroid lipofuscinosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 02:18:13