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Titolo:
Plasma noradrenaline and neuropeptide-Y may not be of primary importance in the pathophysiology of cardiac involvement in systemic sclerosis
Autore:
Kazzam, E; Caidahl, K; Hedner, T; Hedner, J; Waldenstrom, A;
Indirizzi:
Umea Univ Hosp, Ctr Heart, Div Cardiol, S-90185 Umea, Sweden Umea Univ Hosp Umea Sweden S-90185 rt, Div Cardiol, S-90185 Umea, Sweden Sahlgrens Univ Hosp, Dept Clin Physiol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Clin Pharmacol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden
Titolo Testata:
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
fascicolo: 4, volume: 28, anno: 1999,
pagine: 238 - 243
SICI:
0300-9742(1999)28:4<238:PNANMN>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; NONINVASIVE ASSESSMENT; SCLERODERMA; NOREPINEPHRINE; IDENTIFICATION; DYSFUNCTION;
Keywords:
diastolic function; Doppler/echocardiography; left ventricle; neuropeptide-Y; noradrenaline; systolic function; systemic sclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kazzam, E Umea Univ Hosp, Ctr Heart, Div Cardiol, S-90185 Umea, Sweden Umea Univ Hosp Umea Sweden S-90185 rdiol, S-90185 Umea, Sweden
Citazione:
E. Kazzam et al., "Plasma noradrenaline and neuropeptide-Y may not be of primary importance in the pathophysiology of cardiac involvement in systemic sclerosis", SC J RHEUM, 28(4), 1999, pp. 238-243

Abstract

Objective. The present study was performed to measure concentrations of plasma noradrenaline and neuropeptide-Y-like immunoreactivity in relation to cardiac function in patients with systemic sclerosis (SSc). Methods. Plasma noradrenaline was measured by high performance liquid chromatography and neuropeptide-Y by radioimmunoassay in 30 consecutive patients with SSc and 48 sex and age matched controls. Left ventricular (LV) function was evaluated by Echocardiography. Results. There were no significant differences between patients and controls in either plasma noradrenaline or plasma neuropeptide-Y. LV dysfunction and hypertrophy were common among patients. Plasma Neuropeptide-Y was related only to systolic function, while noradrenaline was related to both systolic and diastolic function as well as to LV hypertrophy. Conclusion. Patients with SSc develop different forms of myocardial dysfunction without activation of the sympathetic nervous system as evaluated by plasma noradrenaline and neuropeptide-Y; leaving vascular disease of the heart to be a main candidate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:14:38