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Titolo:
Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice
Autore:
Koster, A; Montkowski, A; Schulz, S; Stube, EM; Knaudt, K; Jenck, F; Moreau, JL; Nothacker, HP; Civelli, O; Reinscheid, RK;
Indirizzi:
Univ Hamburg, Inst Cell Biochem & Clin Neurobiol, D-22529 Hamburg, GermanyUniv Hamburg Hamburg Germany D-22529 Neurobiol, D-22529 Hamburg, Germany Hoffmann La Roche Ag, Div Pharma, CNS Res, CH-4070 Basel, Switzerland Hoffmann La Roche Ag Basel Switzerland CH-4070 H-4070 Basel, Switzerland Otto Von Guericke Univ, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ept Pharmacol, Irvine, CA 92697 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 18, volume: 96, anno: 1999,
pagine: 10444 - 10449
SICI:
0027-8424(19990831)96:18<10444:TDOTOF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; NOCICEPTIN/ORPHANIN FQ; BEHAVIORAL-RESPONSES; TISSUE DISTRIBUTION; INDUCED ANALGESIA; RECEPTOR GENE; TOLERANCE; MORPHINE; ANXIETY; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Reinscheid, RK Univ Hamburg, Inst Cell Biochem & Clin Neurobiol, Suderfeldstr 24, D-22529Hamburg, Germany Univ Hamburg Suderfeldstr 24 Hamburg Germany D-22529 rmany
Citazione:
A. Koster et al., "Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice", P NAS US, 96(18), 1999, pp. 10444-10449

Abstract

The neuropeptide orphanin FQ (also known as nociceptin; OFQ/N) has been implicated in modulating stress-related behavior. OFQ/N was demonstrated to reverse stress-induced analgesia and possess anxiolytic-like activity after central administration, To further study physiological functions of OFQ/N, we have generated OFQ/N-deficient mice by targeted disruption of the OFQ/N gene. Homozygous mice display increased anxiety-like behavior when exposed to a novel and threatening environment. OFQ/N-null mice show elevated basalpain threshold but develop normal stress-induced analgesia, Interestingly,these mice show impaired adaptation to repeated stress when compared with wild-type mice, whereas their performance in spatial learning remained unaffected, Basal and poststress plasma corticosterone levels were found to be elevated in OFQ/N-deficient animals. Thus, OFQ/N appears to be crucially involved in the neurobiological regulation of stress-coping behavior and fear.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:44:11