Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Identification of system y(+)L as the high-affinity transporter for L-arginine in human platelets: up-regulation of L-arginine influx in uraemia
Autore:
Ribeiro, ACM; Brunini, TMC; Yaqoob, M; Aronson, JK; Mann, GE; Ellory, JC;
Indirizzi:
Univ Oxford, Physiol Lab, Oxford OX1 3PT, England Univ Oxford Oxford England OX1 3PT Physiol Lab, Oxford OX1 3PT, England Royal London Hosp, Dept Nephrol, London E1 1BB, England Royal London HospLondon England E1 1BB Nephrol, London E1 1BB, England Univ Oxford, Radcliffe Infirm, Dept Clin Pharmacol, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE in Pharmacol, Oxford OX2 6HE, England Univ London Kings Coll, GKT Sch Biomed Sci, Ctr Cardiovasc Biol & Med, London W8 7AH, England Univ London Kings Coll London England W8 7AH Med, London W8 7AH, England
Titolo Testata:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
fascicolo: 4, volume: 438, anno: 1999,
pagine: 573 - 575
SICI:
0031-6768(199909)438:4<573:IOSYAT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; SODIUM;
Keywords:
L-arginine; amino acid transport; system y(+)L; platelets; uraemia; nitric oxide; chronic renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Ribeiro, ACM Univ Oxford, Physiol Lab, S Parks Rd, Oxford OX1 3PT, EnglandUniv Oxford S Parks Rd Oxford England OX1 3PT 1 3PT, England
Citazione:
A.C.M. Ribeiro et al., "Identification of system y(+)L as the high-affinity transporter for L-arginine in human platelets: up-regulation of L-arginine influx in uraemia", PFLUG ARCH, 438(4), 1999, pp. 573-575

Abstract

Kinetic studies of L-arginine transport in human platelets have identifieda high-affinity, low-capacity transport system [Michaelis-Menten constant (K-m,) about 10 mu M] for cationic amino acids that also transports neutralamino acids with high affinity in the presence of Na+ but not Kf. These characteristics, together with our kinetic cis-inhibition studies, indicate that saturable L-arginine transport in human platelets is mediated via the system y(+)L and not the classic cationic transporter system y(+). We present here the first evidence that L-arginine transport via system y(+)L is increased twofold in platelets from patients with chronic renal failure. System y(+)L has been described in human erythrocytes, peripheral blood mononuclear cells and placenta, and up-regulation of system y+L activity in human platelets could explain the paradox of increased nitric oxide (NO) production by uraemic platelets under conditions of decreased plasma L-arginine and elevated NG-monomethyl-L-arginine (L-NMMA) concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 09:28:32