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Titolo:
Neurotoxicity of glutamate at the concentration released upon spinal cord injury
Autore:
Liu, D; Xu, GY; Pan, E; McAdoo, DJ;
Indirizzi:
Univ Texas, Med Branch, Inst Marine Biomed, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 Marine Biomed, Galveston, TX 77555 USA Univ Texas, Med Branch, Dept Neurol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 h, Dept Neurol, Galveston, TX 77555 USA Univ Texas, Med Branch, Dept Human Biol Chem & Genet, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 l Chem & Genet, Galveston, TX 77555 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 93, anno: 1999,
pagine: 1383 - 1389
SICI:
0306-4522(1999)93:4<1383:NOGATC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; MODEL COMBINING MICRODIALYSIS; KAINIC ACID; SECONDARY DAMAGE; RAT STRIATUM; QUANTITATIVE MICRODIALYSIS; FUNCTIONAL DEFICITS; CHRONIC INFUSION; NERVOUS-SYSTEM; CELL-CULTURE;
Keywords:
amino acid release; contusion model; excitotoxicity; microdialysis; rat; secondary damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: McAdoo, DJ Univ Texas, Med Branch, Inst Marine Biomed, Galveston, TX 77555USA Univ Texas Galveston TX USA 77555 med, Galveston, TX 77555 USA
Citazione:
D. Liu et al., "Neurotoxicity of glutamate at the concentration released upon spinal cord injury", NEUROSCIENC, 93(4), 1999, pp. 1383-1389

Abstract

Damage caused by administering glutamate into the spinal cord was characterized histologically. Glutamate destroyed neurons for several hundred micrometers around the administering microdiaIysis fiber. At 24h after treatment, significant (P = 0.036) loss of neurons was observed (75%) relative to control (47%) near the fiber when glutamate was administered for 1 h at a concentration outside the fiber approximating the maximum glutamate released upon spinal cord injury. Significant loss of neurons (P = 0.006, 0.022) was also caused by administering a combination of glutamate at about its average concentration released upon injury over the 1 h period of administration in combination with the maximum aspartate concentration released upon injury. This work provides a direct demonstration that the concentrations of excitatory amino acids released upon spinal cord injury are neurotoxic. The destruction of neurons by exposure to excitatory amino acids when there is alsosubstantial loss of neurons simply from the presence of the microdialysis fiber may reflect sensitization of neurons to excitotoxicity by stress. (C)1999 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 12/07/20 alle ore 06:35:35