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Titolo:
Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia
Autore:
Chang, L; Ernst, T; Leonido-Yee, M; Witt, M; Speck, O; Walot, I; Miller, EN;
Indirizzi:
Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Sch Med, Dept Neurol, Torrance, CA 90502 USA Univ Calif Los Angeles Torrance CA USA 90502 urol, Torrance, CA 90502 USA Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Sch Med, Dept Radiol, Torrance, CA 90502 USA Univ Calif Los Angeles Torrance CA USA 90502 diol, Torrance, CA 90502 USA Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Sch Med, Dept Med,Torrance, CA 90502 USA Univ Calif Los Angeles Torrance CA USA 90502 t Med,Torrance, CA 90502 USA Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Sch Med, Dept Psychiat, Torrance, CA 90502 USA Univ Calif Los Angeles Torrance CA USA 90502 hiat, Torrance, CA 90502 USA
Titolo Testata:
NEUROLOGY
fascicolo: 4, volume: 53, anno: 1999,
pagine: 782 - 789
SICI:
0028-3878(19990911)53:4<782:HAATRB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; MULTICENTER AIDS COHORT; PROTON MR SPECTROSCOPY; ABSOLUTE QUANTITATION; CLINICAL-FEATURES; INFECTED PATIENTS; FRONTAL-LOBE; INDIVIDUALS; COMPARTMENTS;
Keywords:
MRI; MRS; HIV dementia; highly active antiretroviral therapy; metabolites;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, L Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Sch Med, Dept Neurol, 1124 W Carson St,B-4, Torrance, CA 90502 USA Univ Calif Los Angeles 1124 W Carson St,B-4 Torrance CA USA 90502
Citazione:
L. Chang et al., "Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia", NEUROLOGY, 53(4), 1999, pp. 782-789

Abstract

Objective: To determine whether cerebral metabolite abnormalities normalize with highly active antiretroviral therapy (HAART). Background: Patients with HIV-cognitive motor complex (HIV-CMC) show cerebral metabolite abnormalities in the early stages of dementia. Methods: Sixteen patients with HIV-CMC were evaluated before and after HAART, and compared with 15 HIV-negativehealthy volunteers. Cerebral metabolite ratios and concentrations in the frontal. lobe and basal ganglia were measured. using proton MRS (H-1 MRS). Results: In 14 of 16 patients who tolerated HAART, CD4 count increased by 133 +/- 101 cells/mm(3) (p = 0.0003), HIV Dementia Scale score increased by 1.8 +/- 2.4 points (p = 0.02), and AIDS dementia complex (ADC) stage decreased by 0.54 +/- 0.54 points (p = 0.003). The initially increased choline/creatine (CHO/CR) reversed in the midfrontal cortex (-8.0%; p = 0.02) and in the basal ganglia (-14.7%; p = 0.01). The initially elevated myoinositol (MI)/CR and myoinositol concentration [MI] in the basal ganglia also decreased(MI/CR: -14.1%; p = 0.005; [MI]: 11.8%; p = 0.02), along with normalization of [MI] in the frontal white matter (11.4%; p = 0.05). Furthermore, the change in [MI] in the frontal white matter correlated with the change in CD4count (r = -0.67, p = 0.03) and with the change in ADC stage(p = 0.04). Conclusions: HAART improves HIV-CMC in addition to systemic measures of HIV infection. H-1 MRS detects improvement of brain injury measured by cerebral metabolites, particularly the glial marker [MI], in patients with early HIV-CMC after HAART. In addition, the degree of improvement in clinical severity of HIV-CMC is related to the degree of recovery with [MI].

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 22:58:41