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Titolo:
Involvement of delta-opioid receptors in pentylenetetrazol kindling development and kindling-related processes in rats
Autore:
Grecksch, G; Becker, A; Schroeder, H; Hollt, V;
Indirizzi:
Otto Von Guericke Univ, Fac Med, Dept Pharmacol & Toxicol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 2, volume: 360, anno: 1999,
pagine: 151 - 156
SICI:
0028-1298(199908)360:2<151:IODRIP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; BETA-ENDORPHIN; EPILEPTIC PROPERTIES; ENDOGENOUS OPIATES; GLUTAMATE BINDING; MULTIPLE OPIATE; DENTATE GYRUS; SEIZURES; MORPHINE;
Keywords:
delta-opioid receptors; kindling; learning deficit; naltrindole; pentylenetetrazol; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Grecksch, G Otto Von Guericke Univ, Fac Med, Dept Pharmacol & Toxicol, Leipziger Str 44, D-39120 Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
G. Grecksch et al., "Involvement of delta-opioid receptors in pentylenetetrazol kindling development and kindling-related processes in rats", N-S ARCH PH, 360(2), 1999, pp. 151-156

Abstract

The role of delta-opioid receptors on the development of kindling induced by the convulsant pentylenetetrazol (37.5 mg kg(-1) i.p.) was investigated in rats. Besides the seizure development, the kindling induced enhancement of glutamate binding and the kindling-induced learning deficit were examined. A clear depression of kindling development by blocking of delta-opioid receptors by intracerebroventricular administration of naltrindole (10 nmol/5 mu l) was found. In an acute convulsion test performed 8 days after kindling completion, animals pretreated with naltrindole during kindling induction showed lower seizure stages compared to saline-pretreated kindled animals. The kindling-induced increase in hippocampal glutamate binding was completely prevented by naltrindole, whereas the kindling-induced learning deficit was not influenced. The learning performance of control animals pretreated with naltrindole was very low. It was hypothesized that the various consequences of kindling induction could be influenced separately. Summarizing the results, an involvement of the delta-opioid system in mechanisms underlying chemical kindling was clearly demonstrated. Interactions of endogeneous opioid systems with glutamatergic transmission were suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:36:26