Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Combining environmental exposure and genetic effect measurements in healthoutcome assessment
Autore:
Bonassi, S;
Indirizzi:
Ist Nazl Ric Canc, Dept Environm Epidemiol, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 nm Epidemiol, I-16132 Genoa, Italy
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 428, anno: 1999,
pagine: 177 - 185
SICI:
1386-1964(19990716)428:1-2<177:CEEAGE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOMAL-ABERRATIONS; CANCER; LYMPHOCYTES; BIOMARKERS; HUMANS; RISK;
Keywords:
environmental exposure; surrogate end-points of cancer; biomarker; attributable proportion; molecular epidemiology; chromosomal aberration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Bonassi, S Ist Nazl Ric Canc, Dept Environm Epidemiol, Largo Rosanna Benzi10, I-16132 Genoa, Italy Ist Nazl Ric Canc Largo Rosanna Benzi 10 Genoa Italy I-16132 y
Citazione:
S. Bonassi, "Combining environmental exposure and genetic effect measurements in healthoutcome assessment", MUT RES-F M, 428(1-2), 1999, pp. 177-185

Abstract

The presence of overwhelming difficulties in assessing the extent or even the presence of a causal association between modern environmental exposuresand disease has promoted the use of more complex models in the design of human biomonitoring studies. The concatenation of environmental exposure, genetic effect and individual susceptibility is a key issue in the assessmentof risks for populations exposed to environmental pollutants. The use of abiological event laying in the causal pathway from exposure to outcome as surrogate end-point of disease, can potentially anticipate clinical diagnosis, offering a number of possibilities for application of preventive measures. Numerous biomarkers are currently employed to study human populations exposed to environmental carcinogens, among these, the frequency of chromosomal aberration (CA) in peripheral blood lymphocytes has the most abundant literature linking a genetic effect with the occurrence of cancer. Findings from recent epidemiological studies which have followed-up a large group ofhealthy subjects screened for CAs have lent further support to the use of chromosomal breakage as a relevant biomarker of cancer risk. The applicability of surrogate end-points of cancer on an individual basis thus far seemsto be limited to few examples. On the other hand, from a public health outlook, increases in the frequency of surrogate end-points are suggestive of an increased risk of cancer, and for validated biomarkers such as CAs intervention policies and actions in exposed populations showing increased frequency of these end-points should be always recommended. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:25:30