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Titolo:
Role of alpha(v) integrins in adenovirus cell entry and gene delivery
Autore:
Nemerow, GR; Stewart, PL;
Indirizzi:
Scripps Clin & Res Inst, Dept Immunol, La Jolla, CA 92037 USA Scripps Clin& Res Inst La Jolla CA USA 92037 nol, La Jolla, CA 92037 USA
Titolo Testata:
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
fascicolo: 3, volume: 63, anno: 1999,
pagine: 725 -
SICI:
1092-2172(199909)63:3<725:ROAIIA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-MEDIATED ENDOCYTOSIS; BONE-MARROW TRANSPLANTATION; EPIDERMAL GROWTH-FACTOR; PENTON-BASE; NUCLEOTIDE-SEQUENCE; ACTIN CYTOSKELETON; COXSACKIEVIRUS A9; MAMMALIAN-CELLS; CYSTIC-FIBROSIS; MESSENGER-RNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Nemerow, GR Scripps Clin & Res Inst, Dept Immunol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd LaJolla CA USA 92037
Citazione:
G.R. Nemerow e P.L. Stewart, "Role of alpha(v) integrins in adenovirus cell entry and gene delivery", MICRO M B R, 63(3), 1999, pp. 725

Abstract

Adenoviruses (Ad) are a significant cause of acute infections in humans; however, replication-defective forms of this virus are currently under investigation for human gene therapy Approximately 20 to 25% of all the gene therapy trials (phases I to III) conducted over the past 10 years involve the use of Ad gene delivery for treatment inherited or acquired diseases. At present, the most promising applications involve the use of Ad vectors to irradicate certain nonmetastatic tumors and to promote angiogenesis in order to alleviate cardiovascular disease. While specific problems of using Ad vectors remain to be overcome las is true for almost all viral and nonviral delivery methods), a distinct advantage of Ad is the extensive knowledge of its macromolecular structure, genome organization, sequence, and mode of replication. Moreover, significant information has also been acquired on the interaction of Ad particles with distinct host cell receptors, events which strongly affect virus tropism. This review provides an overview of the structure and function of Ad attachment (coxsackievirus and Ad receptor [CAR]) and internalization (alpha(nu) integrins) receptors and discusses their precise role in virus infection and gene delivery. Recent structure studies ofintegrin-Ad complexes by cryoelectron microscopy are also highlighted. Finally, unanswered questions arising from the current state of knowledge of Ad-receptor interactions are presented in the context of improving Ad vectors for future human gene therapy applications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:38:26