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Titolo:
Involvement of peripheral type of benzodiazepine receptor in social isolation stress-induced decrease in pentobarbital sleep in mice
Autore:
Dong, E; Matsumoto, K; Watanabe, H;
Indirizzi:
Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Oriental Med, Dept Pharmacol, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ Toyama Japan 9300194 Toyama 9300194, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 15, volume: 65, anno: 1999,
pagine: 1561 - 1568
SICI:
0024-3205(19990903)65:15<1561:IOPTOB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROID-BIOSYNTHESIS; BINDING-SITES; LIGANDS; BRAIN; NEUROSTEROIDS; PREGNENOLONE; STEROIDOGENESIS; HYPERACTIVITY; TRANSLOCATION; DERIVATIVES;
Keywords:
social isolation stress; pentobarbitol-induced sleep; peripheral-type benzodiazepine receptors; mitochondrial benzodiazepine receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, K Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Oriental Med, Dept Pharmacol, 2630 Sugitani, Toyama 9300194, Japan Toyama Med & Pharmaceut Univ 2630 Sugitani Toyama Japan 9300194
Citazione:
E. Dong et al., "Involvement of peripheral type of benzodiazepine receptor in social isolation stress-induced decrease in pentobarbital sleep in mice", LIFE SCI, 65(15), 1999, pp. 1561-1568

Abstract

Our previous studies have shown that central-type benzodiazepine (BZD) receptors (CBR) and neurosteroids capable of modulating GABA(A) receptor function are involved in the decrease of pentobarbital (PB)-induced sleep causedby social isolation stress in mice. In this study, to further clarify the mechanism underlying this decrease, we investigated the possible involvement of peripheral-type BZD receptors (PBR) which play an important role in neurosteroidogenesis in PB sleep in socially isolated mice. Socially isolatedmice showed significantly shorter duration of PB-induced sleep than group-housed animals. When injected intracerebroventricularly (i.c.v.), FGIN-1-27(FGIN, 25-100 nmol), a selective PER agonist, and PK11195 (PK, 14-28 nmol),a PER antagonist,and pregnenolone (PREG, 15-30 nmol), a neurosteroid precursor, dose-dependently normalized the PB sleep in isolated mice without having an effect on the group-housed animals. In contrast, pregnenolone sulfate (PS, 24 nmol), an endogenous neurosteroidal negative allosteric modulatorof the GABA(A) receptor, reduced PB sleep in group-housed but not isolatedmice. PS, at the same dose, significantly attenuated the effects of FGIN (100 nmol), PK (28 nmol) and PREG (30 nmol) in isolated mice, while FGIN (100 nmol), PK(28 nmol) and pregnenolone (30 nmol) significantly blocked the effect of PS (24 nmol) in group-housed mice. These results suggest that the PER-mediated decrease in the genesis of neurosteroid(s) possessing a GABA(A) receptor agonistic profile is also partly involved in the down regulationof the GABA(A) receptor following long-term social isolation and contributes to the decrease of PB-induced sleep in isolation stressed mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:06:28