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Titolo:
Leukocyte sequestration in pulmonary microvessels and lung injury following systemic complement activation in rabbits
Autore:
Kuhnle, GEH; Kiefmann, R; Sckell, A; Kuebler, WM; Groh, J; Goetz, AE;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Dept Anesthesiol, D-81366 Munich, Germany Univ Munich Munich Germany D-81366 Anesthesiol, D-81366 Munich, Germany Univ Munich, Inst Surg Res, D-81366 Munich, Germany Univ Munich Munich Germany D-81366 nst Surg Res, D-81366 Munich, Germany
Titolo Testata:
JOURNAL OF VASCULAR RESEARCH
fascicolo: 4, volume: 36, anno: 1999,
pagine: 289 - 298
SICI:
1018-1172(199907/08)36:4<289:LSIPMA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; NEUTROPHIL SEQUESTRATION; CHEMOTACTIC FACTORS; ADHESION MOLECULES; BETA-2 INTEGRINS; P-SELECTIN; MICROCIRCULATION; INFLAMMATION; KINETICS; PLASMA;
Keywords:
pulmonary microcirculation; leukocytes; microscopy; complement activation; cobra venom;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kuhnle, GEH Univ Munich, Klinikum Grosshadern, Dept Anesthesiol, Marchioninistr 15, D-81366 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81366 Germany
Citazione:
G.E.H. Kuhnle et al., "Leukocyte sequestration in pulmonary microvessels and lung injury following systemic complement activation in rabbits", J VASC RES, 36(4), 1999, pp. 289-298

Abstract

Inflammatory reactions are associated with sequestration of leukocytes in the lung. Complement activation leads to accumulation of leukocytes in alveolar septa and alveoli, to lung edema and hemorrhage. Although in organs other than the lung leukocytes interact with the vascular endothelium only inpostcapillary venules, alveolar capillaries are considered to be the site of leukocyte sequestration in the lung. However, pulmonary venules and arterioles have not been investigated systematically after complement activation so far, A closed thoracic window was implanted in anesthetized rabbits; leukocytes and red blood cells were stained, and the movement of these cellswas measured in superficial pulmonary arterioles, venules and alveolar capillaries using fluorescence video microscopy before and 30 and 60 min afterinfusion of cobra venom factor (CVF). Erythrocyte velocity and macrohemodynamic conditions did not change after CVF infusion and were not different from the sham-treated controls. The number of sticking leukocytes increased significantly compared to baseline and control: by 150% in arterioles and in venules and by 740% in alveolar capillaries within 60 min after CVF infusion. The width of alveolar septa in vivo was significantly enlarged after CVF infusion, indicating interstitial pulmonary edema. At the end of the experiments, myeloperoxidase activity was higher in the CVF group, showing leukocyte sequestration in the whole organ. It is concluded that complement activation by CVF induces leukocyte sequestration in lung arterioles, venulesand alveolar capillaries and leads to mild lung injury.

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Documento generato il 17/01/21 alle ore 17:16:58