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Titolo:
Is cardiopulmonary bypass still the cause of cognitive dysfunction after cardiac operations?
Autore:
Taggart, DP; Browne, SM; Halligan, PW; Wade, DT;
Indirizzi:
John Radcliffe Hosp, Oxford Heart Ctr, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Ctr, Oxford OX3 9DU, England Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England Rivermead Rehabil Ctr, Oxford OX1 4XD, England Rivermead Rehabil Ctr Oxford England OX1 4XD tr, Oxford OX1 4XD, England
Titolo Testata:
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
fascicolo: 3, volume: 118, anno: 1999,
pagine: 414 - 420
SICI:
0022-5223(199909)118:3<414:ICBSTC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY BYPASS; OPEN-HEART-SURGERY; GENERAL-ANESTHESIA; NEUROPSYCHOLOGICAL CONSEQUENCES; MICROEMBOLI; PRESSURE; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Taggart, DP John Radcliffe Hosp, Oxford Heart Ctr, Oxford OX3 9DU, EnglandJohn Radcliffe Hosp Oxford England OX3 9DU OX3 9DU, England
Citazione:
D.P. Taggart et al., "Is cardiopulmonary bypass still the cause of cognitive dysfunction after cardiac operations?", J THOR SURG, 118(3), 1999, pp. 414-420

Abstract

Objective: The purpose of this study was to determine whether cognitive impairment is related to cardiopulmonary bypass, Methods: Twenty-five patients undergoing coronary artery bypass grafting without cardiopulmonary bypasswere matched with 50 patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. All patients received the same anesthetic regimen, and one surgeon performed all the operations. A battery of 10 standard tests of neuropsychologic function were performed before, at discharge, and3 months after the operation. A comprehensive multidimensional measure of subjective health status was used as the primary clinical measure of functional outcome, Results: The groups were similar with respect to age, sex, and ventricular function and differed only in the need for a circumflex artery graft. Both groups showed significant improvement in the comprehensive multidimensional measure of subjective health status at 3 months, At discharge most neuropsychologic tests had deteriorated in both groups (the same 4 tests had deteriorated significantly in both groups, and an additional test had deteriorated significantly in the cardiopulmonary bypass group). At 3 months all but one test in the cardiopulmonary bypass group had returned to or exceeded baseline performance. The same 2 tests had improved significantly in both groups, and a further test had improved significantly in the group without cardiopulmonary bypass. At no specific time point was there a significant difference between the absolute or change scores between the groups on any of the tests. Conclusions: The similar pattern of early decline and late recovery of cognitive function in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass suggests that cardiopulmonary bypass is not the major cause of postoperative cognitive impairment. This merits consideration in deciding optimal treatment strategies in coronary revascularization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:17:34