Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Frequency characteristics of blood pressure oscillations evoked by sympathetic transmitters, noradrenaline and adenosine triphosphate
Autore:
Golubinskaya, VO; Tarasova, OS; Borovik, AS; Rodionov, IM;
Indirizzi:
Moscow MV Lomonosov State Univ, Fac Biol, Dept Human & Anim Physiol, Moscow 119899, Russia Moscow MV Lomonosov State Univ Moscow Russia 119899 oscow 119899, Russia AV Vishnevskii Surg Inst, Moscow 113811, Russia AV Vishnevskii Surg Inst Moscow Russia 113811 nst, Moscow 113811, Russia
Titolo Testata:
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
fascicolo: 1, volume: 77, anno: 1999,
pagine: 13 - 20
SICI:
0165-1838(19990707)77:1<13:FCOBPO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENTERIC ARTERIAL BED; HEART-RATE; SPECTRAL-ANALYSIS; CARDIOVASCULAR VARIABILITY; PURINERGIC NEUROTRANSMISSION; CONSCIOUS RATS; MAYER WAVES; PPADS; P-2X-PURINOCEPTORS; TRANSMISSION;
Keywords:
ATP; blood pressure variability; Fourier analysis; noradrenaline; PPADS; sympathetic nervous system; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Rodionov, IM Moscow MV Lomonosov State Univ, Fac Biol, Dept Human & Anim Physiol, Vorobiov Hills, Moscow 119899, Russia Moscow MV Lomonosov State Univ Vorobiov Hills Moscow Russia 119899
Citazione:
V.O. Golubinskaya et al., "Frequency characteristics of blood pressure oscillations evoked by sympathetic transmitters, noradrenaline and adenosine triphosphate", J AUTON NER, 77(1), 1999, pp. 13-20

Abstract

Mean arterial pressure (MAP) was recorded beat-to-beat in chronically instrumented, conscious, unrestrained rats under control conditions and after pharmacological inhibition of vascular sympathetic influences by means of: (1) ganglion blockade with chlorisondamine; (2) alpha-adrenoceptor antagonist phentolamine; (3) P2 receptor blockade with pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS). Angiotensin II was continuously infused to prevent drastic MAP decrease during chlorisondamine and phentolamine administration. Overall MAP variability increased after ganglion blockade and combined blockade of adreno- and purinoceptors. It increased also after inhibition of purinergic influences, but was not significantly changed after vascular adrenergic blockade. Spectral analysis of spontaneous MAP fluctuations in intact rats revealed a peak centered at 0.4-0.5 Hz. Ganglion blockadesuppressed MAP fluctuations with frequencies from 0.1 to 0.8 Hz. After blockade of alpha-adrenoceptors, MAP spectral density was suppressed only within the 0.1-0.45-Hz band, but increased in the 0.45-0.8-Hz band. In the latter case, sympathetically-induced peak of MAP spectrum was centered on 0.6 Hz, being evoked, presumably, by adenosine triphosphate (ATP). Blockade of P2 receptors by PPADS enhanced MAP fluctuations in the 0.1-0.45-Hz frequencyband, i.e. the noradrenaline-induced peak was centered on 0.2 Hz. No peaksEvert observed in the 0.1-0.8-Hz frequency band during combined blockade of adreno- and purinoceptors. The present study supports the concept that sympathetic purinergic co-transmission is essential for stabilization of MAP level. MAP fluctuations evoked by noradrenaline and ATP can be distinguished by their frequency characteristics. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:59:22