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Titolo:
Oral delivery of insulin using pH-responsive complexation gels
Autore:
Lowman, AM; Morishita, M; Kajita, M; Nagai, T; Peppas, NA;
Indirizzi:
Purdue Univ, Sch Chem Engn, Biomat & Drug Delivery Labs, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 very Labs, W Lafayette, IN 47907 USA Hoshi Univ, Dept Pharmaceut, Tokyo 142, Japan Hoshi Univ Tokyo Japan 142Hoshi Univ, Dept Pharmaceut, Tokyo 142, Japan
Titolo Testata:
JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 9, volume: 88, anno: 1999,
pagine: 933 - 937
SICI:
0022-3549(199909)88:9<933:ODOIUP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL-TRACT; DRUG-DELIVERY; PEPTIDE; MICROSPHERES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Peppas, NA Purdue Univ, Sch Chem Engn, Biomat & Drug Delivery Labs, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 W Lafayette, IN 47907 USA
Citazione:
A.M. Lowman et al., "Oral delivery of insulin using pH-responsive complexation gels", J PHARM SCI, 88(9), 1999, pp. 933-937

Abstract

The goal of oral insulin delivery devices is to protect the sensitive drugfrom proteolytic degradation in the stomach and upper portion of the smallintestine. In this work, we investigate the use of pH-responsive, poly(methacrylic-g-ethylene glycol) hydrogels as oral delivery vehicles for insulin. Insulin was loaded into polymeric microspheres and administered orally tohealthy and diabetic Wistar rats, In the acidic environment of the stomach, the gels were unswollen due to the formation of intermolecular polymer complexes. The insulin remained in the gel and was protected from proteolyticdegradation. In the basic and neutral environments of the intestine, the complexes dissociated which resulted in rapid gel swelling and insulin release. Within 2 h of administration of the insulin-containing polymers, strongdose-dependent hypoglycemic effects were observed in both healthy and diabetic rats. These effects lasted for up to 8 h following administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:14:11