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Titolo:
A reverse flow-metabolism mismatch pattern on PET is related to multivessel disease in patients with acute myocardial infarction
Autore:
Yamagishi, H; Akioka, K; Hirata, K; Sakanoue, Y; Takeuchi, K; Yoshikawa, J; Ochi, H;
Indirizzi:
Osaka City Univ, Sch Med, Dept Internal Med 1, Abeno Ku, Osaka 5458586, Japan Osaka City Univ Osaka Japan 5458586 ed 1, Abeno Ku, Osaka 5458586, Japan Osaka City Univ, Sch Med, Div Nucl Med, Osaka 545, Japan Osaka City Univ Osaka Japan 545 Sch Med, Div Nucl Med, Osaka 545, Japan
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 9, volume: 40, anno: 1999,
pagine: 1492 - 1498
SICI:
0161-5505(199909)40:9<1492:ARFMPO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; POSITRON EMISSION TOMOGRAPHY; EXERCISE RADIONUCLIDE ANGIOGRAPHY; VIABLE MYOCARDIUM; OXIDATIVE-METABOLISM; THROMBOLYTIC THERAPY; N-13 AMMONIA; BLOOD-FLOW; FOLLOW-UP; IDENTIFICATION;
Keywords:
PET; myocardial infarction; multivessel disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Yamagishi, H Osaka City Univ, Sch Med, Dept Internal Med 1, Abeno Ku, 1-5-7 Asahi Machi, Osaka 5458586, Japan Osaka City Univ 1-5-7 Asahi Machi Osaka Japan 5458586 Japan
Citazione:
H. Yamagishi et al., "A reverse flow-metabolism mismatch pattern on PET is related to multivessel disease in patients with acute myocardial infarction", J NUCL MED, 40(9), 1999, pp. 1492-1498

Abstract

Hypoperfused myocardium with increased uptake of F-18- fluorodeoxyglucose (FDG) is considered to be ischemic but viable myocardium. However, the significance of a more severe detect of FDG than of N-13 ammonia (NH3) (i.e., reverse flow-metabolism mismatch) is not well understood. Methods: To study a reverse flow-metabolism mismatch pattern, PET with NH3 and FDG under glucose loading was performed in 35 patients within 2 wk after onset of first acute myocardial infarction (AMI) and in 29 patients with old myocardial infarction (OMI). The left ventricle was divided into nine segments on a bull's eye polar map, and the mean counts of NH3 (%NH3) and FDG (%FDG) were compared for the segment with the least %NH3. Results: Ten patients in the AMI group demonstrated a marked reverse flow-metabolism mismatch pattern (greater than 10% difference between %NH3 and %FDG), whereas only 2 patients in the OMI group demonstrated the mismatch pattern (P < 0.05). Sixteen patientswith AMI demonstrated %FDG > %NH3 (group 1), and 19 patients with AMI demonstrated %FDG < %NH3 (group 2). There were no significant differences in age, sex, location of infarction, diameter of stenosis of infarct-related artery or left ventricular ejection fraction between groups 1 and 2. Eleven patients in group 2 and only 3 in group 1 had multivessel disease (P < 0.02). There was no significant relationship between the number of diseased vessels and the flow-metabolism pattern in patients with OMI. Conclusion: The finding of a reverse flow-metabolism mismatch on PET in the subacute phase ofmyocardial infarction was closely related to multivessel disease.

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Documento generato il 20/01/20 alle ore 22:54:26