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Titolo:
Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states
Autore:
Honore, P; Menning, PM; Rogers, SD; Nichols, ML; Basbaum, AI; Besson, JM; Mantyh, PW;
Indirizzi:
Univ Minnesota, Dept Prevent Sci Psychiat & Neurosci, Neurosyst Ctr, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 st Ctr, Minneapolis, MN 55455 USA Vet Affairs Med Ctr, Minneapolis, MN 55417 USA Vet Affairs Med Ctr Minneapolis MN USA 55417 r, Minneapolis, MN 55417 USA Univ Calif San Francisco, Dept Anat & Physiol, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA INSERM, U161, F-75014 Paris, France INSERM Paris France F-75014INSERM, U161, F-75014 Paris, France
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 17, volume: 19, anno: 1999,
pagine: 7670 - 7678
SICI:
0270-6474(19990901)19:17<7670:SSPREA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; DORSAL HORN NEURONS; CARRAGEENAN-INDUCED INFLAMMATION; SPINOTHALAMIC TRACT NEURONS; FORMALIN-INDUCED ACTIVITY; C-FOS EXPRESSION; TRANSGANGLIONIC TRANSPORT; MECHANICAL STIMULATION; CUTANEOUS HYPERALGESIA; NEUROKININ-1 RECEPTOR;
Keywords:
carrageenan; complete Freund adjuvant; formalin; inflammation; internalization; pain; spinal cord; substance P receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Mantyh, PW Univ Minnesota, Dept Prevent Sci Psychiat & Neurosci, NeurosystCtr, 18-208 Moos Tower,515 Delaware St, Minneapolis, MN 55455 USA Univ Minnesota 18-208 Moos Tower,515 Delaware St Minneapolis MN USA 55455
Citazione:
P. Honore et al., "Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states", J NEUROSC, 19(17), 1999, pp. 7670-7678

Abstract

Inflammatory pain involves the sensitization of both primary afferent and spinal cord neurons. To explore the neurochemical changes that contribute to inflammatory pain, we have examined the expression and ligand-induced internalization of the substance P receptor (SPR) in the spinal cord in acute,shortterm, and long-term inflammatory pain states. These inflammatory models included unilateral injection of formalin (8-60 min), carrageenan (3 hr), and complete Freund's adjuvant (CFA; 3 d) into the rat hindpaw as well asadjuvant-induced polyarthritis (21 d). In acute inflammatory pain there isongoing release of substance P (SP) as measured by SPR internalization in lamina I neurons at both 8 and 60 min after formalin injection. Although there is no tonic release of SP in short-term inflammatory pain, at 3 hr after carrageenan injection, SP is released in response to both noxious and non-noxious somatosensory stimulation with SPR internalization being observed in neurons located in both laminae I and III-IV. In long-term inflammatory pain models (CFA and polyarthritis) the same pattern of SP release and SPR activation occurs as is observed in short-term inflammation with the addition that there is a significant upregulation of the SPR in lamina I neurons. These results suggest that SPR internalization might serve as a marker of the contribution of ongoing primary afferent input in acute and persistent pain states. These stereotypical neurochemical changes suggest that there are unique neurochemical signatures for acute, short-term, and long-term inflammatory pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 03:04:03