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Titolo:
Identification of an interneuronal population that mediates recurrent inhibition of motoneurons in the developing chick spinal cord
Autore:
Wenner, P; ODonovan, MJ;
Indirizzi:
NINDS, Sect Dev Neurobiol, Lab Neural Control, NIH, Bethesda, MD 20892 USANINDS Bethesda MD USA 20892 b Neural Control, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 17, volume: 19, anno: 1999,
pagine: 7557 - 7567
SICI:
0270-6474(19990901)19:17<7557:IOAIPT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENSHAW CELLS; MOTOR-NEURONS; LUMBOSACRAL MOTONEURONS; SYNAPTIC DRIVE; EMBRYO; SPECIFICATION; EXPRESSION; PATTERN; CONNECTIVITY; ORGANIZATION;
Keywords:
spinal interneuron; Renshaw cell; spontaneous activity; imaging; synaptic specificity; spinal cord; chick embryo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Wenner, P NINDS, Sect Dev Neurobiol, Lab Neural Control, NIH, 49 Convent Dr,Bldg 49,Room 3A50, Bethesda, MD 20892 USA NINDS 49 Convent Dr,Bldg 49,Room 3A50 Bethesda MD USA 20892 USA
Citazione:
P. Wenner e M.J. O'Donovan, "Identification of an interneuronal population that mediates recurrent inhibition of motoneurons in the developing chick spinal cord", J NEUROSC, 19(17), 1999, pp. 7557-7567

Abstract

Studies on the development of synaptic specificity, embryonic activity, and neuronal specification in the spinal cord have all been limited by the absence of a functionally identified interneuron class (defined by its uniqueset of connections). Here, we identify an interneuron population in the embryonic chick spinal cord that appears to be the avian equivalent of the mammalian Renshaw cell (R-interneurons). These cells receive monosynaptic nicotinic, cholinergic input from motoneuron recurrent collaterals. They make predominately GABAergic connections back onto motoneurons and to other R-interneurons but project rarely to other spinal interneurons. The similarity between the connections of the developing R-interneuron, shortly after circuit formation, and the mature mammalian Renshaw cell raises the possibilitythat R-interneuronal connections are formed precisely from the onset. Using a newly developed optical approach, we identified the location of R-interneurons in a column, dorsomedial to the motor nucleus. Functional characterization of the R-interneuron population provides the basis for analyses that have so far only been possible for motoneurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:07:27