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Titolo:
TOPOGRAPHY OF HYPOXIC INJURY PROVED BY ARGYROPHILIA IN POSTNATAL RAT-BRAIN
Autore:
MURAMATSU K; FUKUDA A; TOGARI H; NISHINO H;
Indirizzi:
NAGOYA CITY UNIV,SCH MED,MIZUHO KU,MIZUHO CHO NAGOYA AICHI 467 JAPAN NAGOYA CITY UNIV,DEPT PHYSIOL,MIZUHO KU NAGOYA AICHI 467 JAPAN
Titolo Testata:
Pediatric neurology
fascicolo: 2, volume: 16, anno: 1997,
pagine: 105 - 113
SICI:
0887-8994(1997)16:2<105:TOHIPB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; IMMATURE RAT; ISCHEMIC DAMAGE; DARK NEURONS; NEONATAL RAT; HIPPOCAMPUS; VULNERABILITY; NEUROTOXICITY; EXPRESSION; ASPARTATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
K. Muramatsu et al., "TOPOGRAPHY OF HYPOXIC INJURY PROVED BY ARGYROPHILIA IN POSTNATAL RAT-BRAIN", Pediatric neurology, 16(2), 1997, pp. 105-113

Abstract

The argyrophil III method, a new esterification-silver staining approach, was used to elucidate regional differences in the susceptibility of developing brain to hypoxic-ischemic (H-I) injury, We created a unilateral common carotid artery-ligation model with hypoxia (8% oxygen) in postnatal day (P) 7, P14 and P21 rats, The argyrophil (i.e., deteriorated) neurons were apparent in the ipsilateral hippocampus, cortex, and striatum in each age group, Argyrophil neurons exhibited some morphological signs of the ''early phase'' of injury preceding the loss ofstructure and/or cell death in the ''late phase,'' as indicated by hematoxylin-eosin (H-E) staining, The argyrophil neurons were apparent as early as 12 hours after the insult, whereas the histological changesrevealed by H-E staining were subtle, The early phase and late phase histological changes had a stereotyped pattern of appearance in all ages studied, However, the duration of H-I situation required to produceargyrophil cells differed according to age, The most resistive age was P14 (P14 > P7 > P21) in this observation, Therefore, argyrophil III staining is feasible for H-I brain damage model in neonates, The results suggest that both the early phase and the late phase pathological processes after H-I injury have a characteristic topographical vulnerability that does not change during development but have a differing susceptibility according to age. (C) 1997 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 03:30:51