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Titolo:
Biochemical characterization of the epithelial dystroglycan complex
Autore:
Durbeej, M; Campbell, KP;
Indirizzi:
Univ Iowa, Coll Med, Howard Hughes Med Inst, Dept Physiol Biophys, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Physiol Biophys, Iowa City, IA 52242 USA Univ Iowa, Coll Med, Howard Hughes Med Inst, Dept Neurol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 st, Dept Neurol, Iowa City, IA 52242 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 37, volume: 274, anno: 1999,
pagine: 26609 - 26616
SICI:
0021-9258(19990910)274:37<26609:BCOTED>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYSTROPHIN-GLYCOPROTEIN COMPLEX; GIRDLE MUSCULAR-DYSTROPHY; ACETYLCHOLINE-RECEPTOR AGGREGATION; ALPHA-DYSTROGLYCAN; SARCOGLYCAN COMPLEX; DELTA-SARCOGLYCAN; SKELETAL-MUSCLE; NEUROMUSCULAR-JUNCTION; EPSILON-SARCOGLYCAN; MOUSE EMBRYOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Campbell, KP Univ Iowa, Coll Med, Howard Hughes Med Inst, Dept Physiol Biophys, 400 EMRB, Iowa City, IA 52242 USA Univ Iowa 400 EMRB Iowa City IA USA52242 City, IA 52242 USA
Citazione:
M. Durbeej e K.P. Campbell, "Biochemical characterization of the epithelial dystroglycan complex", J BIOL CHEM, 274(37), 1999, pp. 26609-26616

Abstract

Dystroglycan is a widely expressed extracellular matrix receptor that plays a critical role in basement membrane formation, epithelial development, and synaptogenesis. Dystroglycan was originally characterized in skeletal muscle as an integral component of the dystrophin glycoprotein complex, whichis critical for muscle cell viability. Although the dystroglycan complex has been well characterized in skeletal muscle, there is little information on the structural composition of the dystroglycan complex outside skeletal muscle. Here we have biochemically characterized the dystroglycan complex in lung and kidney. We demonstrate that the presence of sarcoglycans and sarcospan in lung reflects association with dystroglycan in the smooth muscle. The smooth muscle dystroglycan complex in lung, composed of dystroglycan, dystrophin/utrophin, beta-, delta-, is an element of-sarcoglycan, and sarcospan, can be biochemically separated from epithelial dystroglycan, which isnot associated with any of the known sarcoglycans or sarcospan. Similarly,dystroglycan in kidney epithelial cells is not associated with any of the sarcoglycans or sarcospan. Thus, our data demonstrate that there are distinct dystroglycan complexes in non-skeletal muscle organs as follows: one from smooth muscle, which is associated with sarcoglycans forming a similar complex as in skeletal muscle, and one from epithelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:54:52