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Titolo:
Roles of ion channels in carotid body chemotransmission of acute hypoxia
Autore:
Shirahata, M; Sham, JSK;
Indirizzi:
Johns Hopkins Med Inst, Dept Environm Hlth Sci, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ci, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Anesthesiol Crit Care Med, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ed, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ed, Baltimore, MD 21205 USA
Titolo Testata:
JAPANESE JOURNAL OF PHYSIOLOGY
fascicolo: 3, volume: 49, anno: 1999,
pagine: 213 - 228
SICI:
0021-521X(199906)49:3<213:ROICIC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICOTINIC ACETYLCHOLINE-RECEPTORS; ARTERIAL CHEMORECEPTOR CELLS; CULTURED GLOMUS CELLS; RAT HIPPOCAMPAL-NEURONS; I CELLS; K+ CHANNELS; CATECHOLAMINE RELEASE; NITRIC-OXIDE; NEONATAL RAT; INTRACELLULAR CALCIUM;
Keywords:
Cl- channel; hypoxia; intracellular calcium; K+ channel; neuronal nicotinic acetylcholine receptor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
130
Recensione:
Indirizzi per estratti:
Indirizzo: Shirahata, M Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Environm Hlth Sci, Div Physiol, 615 N Wolfe St, Baltimore, MD 21205 USA Johns Hopkins Univ615 N Wolfe St Baltimore MD USA 21205 USA
Citazione:
M. Shirahata e J.S.K. Sham, "Roles of ion channels in carotid body chemotransmission of acute hypoxia", JPN J PHYSL, 49(3), 1999, pp. 213-228

Abstract

In this review, we have highlighted the roles of ion channels in carotid body chemo-transmission of acute hypoxia, With the application of new technologies, significant breakthroughs have been made in the last decade. The discovery of oxygen-sensitive K+ channels in rabbit glomus cells has generated the membrane model of hypoxic chemotransmission: the inhibition of oxygen-sensitive K+ channels by hypoxia initiates the depolarization of glomus cells and increases the firing frequency of glomus cells. The depolarization of glomus cells activates voltage-gated Ca2+ channels, elevating intracellular Ca2+ which triggers the release of neurotransmitters, The correlation of these events in rabbit glomus cells has been shown. However, a large corpus of data indicates that various mechanisms may be involved in different species. In rats, Ca2+-activated K+ channels are inhibited by hypoxia, The role of this inhibition on rat glomus cell function is controversial, and the contribution of leak-type K+ channels to rat glomus cell depolarization has recently been proposed. On the other hand, in cats, nicotinic ACh receptors (ligand-gated cation channels) may play a key role in initiating the depolarization of glomus cells and increasing the cytosolic Ca2+ of glomus cells in response to hypoxia, Hypoxic inhibition of oxygen-sensitive K+ channels would participate to further depolarize cat glomus cells. Additionally,the activity of Cl- channels and the modulation of ion channels by neurotransmitters may influence the excitability of glomus cells. For generating action potentials in chemoreceptor afferent nerves, nicotinic ACh receptors appear to be involved in cats and rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:05:37