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Titolo:
Contribution of the cholesteryl ester transfer protein gene TaqIB polymorphism to the reduced plasma HDL-cholesterol levels found in abdominal obese men with the features of the insulin resistance syndrome
Autore:
Vohl, MC; Lamarche, B; Pascot, A; Leroux, G; Prudhomme, D; Bouchard, C; Nadeau, A; Despres, JP;
Indirizzi:
CHU Laval, Lipid Res Ctr, Quebec City, PQ G1V 4G2, Canada CHU Laval Quebec City PQ Canada G1V 4G2 , Quebec City, PQ G1V 4G2, Canada CHU Laval, Diabet Res Unit, Quebec City, PQ G1V 4G2, Canada CHU Laval Quebec City PQ Canada G1V 4G2 , Quebec City, PQ G1V 4G2, Canada Univ Laval, Phys Act Sci Lab, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 t Sci Lab, St Foy, PQ G1K 7P4, Canada
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 9, volume: 23, anno: 1999,
pagine: 918 - 925
SICI:
0307-0565(199909)23:9<918:COTCET>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; BODY-FAT DISTRIBUTION; DEPENDENT DIABETES-MELLITUS; ADIPOSE-TISSUE DISTRIBUTION; CORONARY HEART-DISEASE; VISCERAL OBESITY; CETP GENE; CARDIOVASCULAR-DISEASE; COMPUTED-TOMOGRAPHY; ECORI POLYMORPHISM;
Keywords:
cholesteryl ester transfer protein; abdominal obesity; HDL-cholesterol; hyperinsulinaemia; insulin-resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Despres, JP CHU Laval, Lipid Res Ctr, 2705 Blvd Laurier,CHUQ Pavillon,TR-93, Quebec City, PQ G1V 4G2, Canada CHU Laval 2705 Blvd Laurier,CHUQ Pavillon,TR-93 Quebec City PQ Canada G1V 4G2
Citazione:
M.C. Vohl et al., "Contribution of the cholesteryl ester transfer protein gene TaqIB polymorphism to the reduced plasma HDL-cholesterol levels found in abdominal obese men with the features of the insulin resistance syndrome", INT J OBES, 23(9), 1999, pp. 918-925

Abstract

OBJECTIVE: The aim of this study was to examine the relation between the CETP-TaqIB polymorphism and reduced plasma HDL-cholesterol levels commonly observed among men characterized by abdominal obesity and features of the insulin resistance syndrome. SUBJECTS: A total of 187 sedentary men, non-smokers and free from metabolic disorders were classified on the basis of their CETP-TaqIB genotype. RESULTS: Plasma HDL and HDL3-cholesterol concentrations as well as the CETP activity were significantly different between the three genotypes, B1B1 men having significantly lower HDL and HDL3-cholesterol levels and higher CETP activity than B2B2 homozygotes. A 2x3 ANOVA was used to determine the source of variation of plasma HDL and HDL2-cholesterol levels among the threegenotypic groups of men divided on the basis of either a high (greater than or equal to 27 kg/m(2)) or a low (<27 kg/m(2)) BMI, a high (greater than or equal to 130 cm(2)) or a low (<130 cm(2)) accumulation of visceral adipose tissue assessed by computed tomography, or a low versus a high fasting plasma insulin concentration (using the median value as a cutoff point). Theeffect of the CETP genotype observed on plasma HDL-cholesterol concentrations was attenuated among men with features of the insulin resistance syndrome. It seems that the expected raising effect of the B2 allele on plasma HDL-cholesterol concentrations was blunted in the presence of a BMI greater than or equal to 27 kg/m2, a high accumulation of visceral adipose tissue orhyperinsulinaemia. CONCLUSION: Our data indicate that the CETP gene TaqIB polymorphism influences plasma CETP activity on one hand and plasma HDL-cholesterol concentrations on the other hand among men. The association between the TaqIB polymorphism and plasma HDL-cholesterol concentrations is altered by the presence of abdominal obesity and some features of the insulin resistance syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 13:05:08