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Titolo:
Comparative microsatellite analysis in discerning origin of disseminated tumor: The case of a patient with malignant ascites and a history of multiple tumors
Autore:
Eisenberger, CF; Wu, L; Nicol, T; Shah, SI; Sidransky, D; Westra, WH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Johns Hopkins Med Inst,Div Head & Neck Canc Res, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 k Surg, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Pathol, Baltimore, MD 21205 USA
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 9, volume: 30, anno: 1999,
pagine: 1111 - 1113
SICI:
0046-8177(199909)30:9<1111:CMAIDO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMON CLONAL ORIGIN; 2ND PRIMARY; CANCER; HEAD; CARCINOMAS; LUNG;
Keywords:
microsatellite; loss of heterozygosity; renal cell carcinoma; metastases; 3p;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Sidransky, D Johns Hopkins Univ, Sch Med, Johns Hopkins Med Inst,Div Head & Neck Canc Res, Dept Otolaryngol Head & Neck Surg, 818 Ross Res Bldg,720 Rutland Ave, Baltimore, MD 21205 USA Johns Hopkins Univ 818 Ross Res Bldg,720 Rutland Ave Baltimore MD USA 21205
Citazione:
C.F. Eisenberger et al., "Comparative microsatellite analysis in discerning origin of disseminated tumor: The case of a patient with malignant ascites and a history of multiple tumors", HUMAN PATH, 30(9), 1999, pp. 1111-1113

Abstract

The origin of metastatic carcinoma is now always easily resolved on the basis of conventional clinical and pathological parameters, particularly in patients with more than 1 primary tamer. When I of the tumors is a renal cell carcinoma, the clinical picture is further confounded by the tendency of these tamers to be locally silent, to metastasize to unusual sites, and to disseminate long after removal of the primary tumor. We compared tumors forloss (ie, deletion) of loci on chromosomal arms 3p, 5q, 11q, and 18q in a patient with a malignant ascites fluid, a remote history of renal and colonic neoplasms, and a strong clinical suspicion of disseminated gastrointestinal adenocarcinoma. DNA from microdissected tumors and normal tissues was subjected to polymerase chain reaction-based microsatellite analysis. Even though the clinical picture suggested a gastrointestinal origin, comparison of genetic alterations clearly showed that the malignant ascites represented recurrence of the renal cell carcinoma. The malignant ascites and the primary renal cell carcinoma showed identical patterns of allelic loss at all loci tested. In contrast, the malignant ascites and colonic adenoma showed discordant patterns of allelic loss, Comparative microsatellite analysis provides a rapid genetic approach for discerning the origin of metastatic tumor spread. This may be a useful diagnostic adjunct when tamer origin is notclear on clinical or morphological grounds, In some instances, it may evenprovide a reasonable alternative to an extensive and costly conventional work-up. HUM PATHOL 30:1111-1113. Copyright (C) 1999 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:03:01