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Titolo:
An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: The Adh region
Autore:
Ashburner, M; Misra, S; Roote, J; Lewis, SE; Blazej, R; Davis, T; Doyle, C; Galle, R; George, R; Harris, N; Hartzell, G; Harvey, D; Hong, L; Houston, K; Hoskins, R; Johnson, G; Martin, C; Moshrefi, A; Palazzolo, M; Reese, MG; Spradling, A; Tsang, G; Wan, K; Whitelaw, K; Kimmel, B; Celniker, S; Rubin, GM;
Indirizzi:
Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England Univ Cambridge Cambridge England CB2 3EH net, Cambridge CB2 3EH, England EMBL, European Bioinformat Inst, Cambridge CB10 1SD, England EMBL Cambridge England CB10 1SD format Inst, Cambridge CB10 1SD, England Univ Wales Coll Med, Dept Pathol, Cardiff CF4 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ed Inst, Berkeley, CA 94720 USA Carnegie Inst Washington, Howard Hughes Med Inst, Baltimore, MD USA Carnegie Inst Washington Baltimore MD USA es Med Inst, Baltimore, MD USA Lawrence Berkeley Lab, Berkeley Drosophila Genome Project, Berkeley, CA 94720 USA Lawrence Berkeley Lab Berkeley CA USA 94720 oject, Berkeley, CA 94720 USA
Titolo Testata:
GENETICS
fascicolo: 1, volume: 153, anno: 1999,
pagine: 179 - 219
SICI:
0016-6731(199909)153:1<179:AEOTSO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL AUTOSOMAL REGION; MITOCHONDRIAL-DNA POLYMERASE; MATERNAL-EFFECT MUTATIONS; ARTIFICIAL-CHROMOSOME LIBRARIES; ANGIOTENSIN-CONVERTING ENZYME; PERIPHERAL NERVOUS-SYSTEM; LARGE TRANSPOSING ELEMENT; PROTEIN-KINASE ACTIVITY; REPEATED GENE FAMILIES; YEAST GOLGI-APPARATUS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
261
Recensione:
Indirizzi per estratti:
Indirizzo: Ashburner, M Univ Cambridge, Dept Genet, Downing St, Cambridge CB2 3EH, England Univ Cambridge Downing St Cambridge England CB2 3EH England
Citazione:
M. Ashburner et al., "An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: The Adh region", GENETICS, 153(1), 1999, pp. 179-219

Abstract

A contiguous sequence of nearly 3 Mb from the genome of Drosophila melanogaster has been sequenced from a series of overlapping P1 and BAC clones. This region covers 69 chromosome polytene bands on chromosome arm 2L, including the genetically well-characterized "Adh region. " A computational analysis of the sequence predicts 218 protein-coding genes, 11 tRNAs, and iii transposable element sequences. At least 38 of the protein-coding genes are arranged in clusters of from 2 to 6 closely related genes, suggesting extensive tandem duplication. The gene density is one protein-coding gene every 13 kb; the transposable element density is one element every 171 kb. Of 73 genes in this region identified by genetic analysis, 49 have been located on the sequence; P-element insertions have been mapped to 43 genes. Ninety-five(44%) of the known and predicted genes match a Drosophila EST, and 144 (66%) have clear similarities to proteins in other organisms. Genes known to have mutant phenotypes are more likely to be represented in cDNA libraries, and far more likely to have products similar to proteins of other organisms, than are genes with no known mutant phenotype. Over 650 chromosome aberration breakpoints map to this chromosome region, and their nonrandom distribution on the genetic map reflects variation in gene spacing on the DNA. This is the first large-scale analysis of the genome of D. melanogaster at thesequence level. In addition to the direct results obtained, this analysis has allowed us to develop and test methods that will be needed to interpretthe complete sequence of the genome of this species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:47:21