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Titolo:
Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts
Autore:
Kajita, M; Kinoh, H; Ito, N; Takamura, A; Itoh, Y; Okada, A; Sato, H; Seiki, M;
Indirizzi:
Univ Tokyo, Inst Med Sci, Dept Canc Cell Res, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 Cell Res, Minato Ku, Tokyo 1088639, Japan Kanazawa Univ, Canc Res Inst, Dept Mol Virol & Oncol, Kanazawa, Ishikawa 9200934, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9200934 wa, Ishikawa 9200934, Japan
Titolo Testata:
FEBS LETTERS
fascicolo: 3, volume: 457, anno: 1999,
pagine: 353 - 356
SICI:
0014-5793(19990903)457:3<353:HMTMM(>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGELATINASE-A; CDNA LIBRARY; IDENTIFICATION; ACTIVATION; GENE;
Keywords:
matrix metalloproteinase; membrane-type enzyme; MT4-MMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Seiki, M Univ Tokyo, Inst Med Sci, Dept Canc Cell Res, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 Shirokanedai Tokyo Japan1088639 1088639, Japan
Citazione:
M. Kajita et al., "Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts", FEBS LETTER, 457(3), 1999, pp. 353-356

Abstract

Five distinct membrane-type matrix metalloproteinases (MT-MMP) have been reported by cDNA cloning, However, the mt4-mmp gene product (MMP-17) has notbeen identified yet in spite of the cDNA isolation [Puente ct al, (1996), Cancer Res. 56, 944-949]. In this study, we re-examined the transcripts forhuman mt4-mmp by 5' RACE and identified two types of transcripts. The minor one corresponded to the cDNA reported by Puente et al, and failed to express protein, and the other is the major transcript that has an extended open reading frame and expressed 67 and 71 kDa translation products. Thus, functional mt4-mmp has been identified for the first time. (C) 1999 Federationof European Biochemical Societies.

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Documento generato il 12/08/20 alle ore 00:04:57