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Titolo:
DETECTION OF ELASTIN IN THE HUMAN FETAL MEMBRANES - PROPOSED MOLECULAR-BASIS FOR ELASTICITY
Autore:
HIEBER AD; CORCINO D; MOTOSUE J; SANDBERG LB; ROOS PJ; YEHYU S; CSISZAR K; KAGAN HM; BOYD CD; BRYANTGREENWOOD GD;
Indirizzi:
UNIV HAWAII,DEPT ANAT & REPROD BIOL HONOLULU HI 96822 UNIV HAWAII,DEPT ANAT & REPROD BIOL HONOLULU HI 96822 LOMA LINDA UNIV,JERRY L PETTIS MEM VET AFFAIRS MED CTR LOMA LINDA CA 92357 UNIV ROCHESTER,DEPT OBSTET & GYNECOL NEW YORK NY 14621 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT SURG NEW BRUNSWICK NJ 08903 BOSTON UNIV,SCH MED,DEPT BIOCHEM BOSTON MA 02118
Titolo Testata:
Placenta
fascicolo: 4, volume: 18, anno: 1997,
pagine: 301 - 312
SICI:
0143-4004(1997)18:4<301:DOEITH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYSYL OXIDASE; CERVIX; LOCALIZATION; MICROFIBRILS; EXTRACTION; FIBERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A.D. Hieber et al., "DETECTION OF ELASTIN IN THE HUMAN FETAL MEMBRANES - PROPOSED MOLECULAR-BASIS FOR ELASTICITY", Placenta, 18(4), 1997, pp. 301-312

Abstract

The human fetal membranes provide a sterile biomechanical container which adjust by growth to mid-pregnancy to the increase in fetal size, and by elasticity to the forceful movements of the fetus. The molecular basis for this elasticity is not known, yet reduced elasticity may lead to their premature rupture and preterm birth, a major problem in perinatal medicine. Classically, elastin confers the property of elastic recoil to elastic fibres which are assembled from a family of tropoelastin precursors. These are covalently cross-linked to form insolubleelastin by formation of desmosine and isodesmosine, catalysed by the enzyme lysyl oxidase. The amnion, chorion and decidua were shown by Northern analysis and RT-PCR to contain detectable levels of tropoelastin mRNA and the mRNA encoding lysyl oxidase. The proteins encoded by these mRNAs were also identified by Western blotting and immunolocalization. Further, insoluble elastin was extracted from the human fetal membranes and shown by comparison to elastin preparations from other elastic tissues to have a reasonable desmosine content. Finally, scanning electron microscopy confirmed the presence of multiple layers of an apparently very thin elastic system in this tissue. This biochemical andhistopathologic study has demonstrated therefore that the human fetalmembranes synthesize and deposit a novel elastic fibre. The presence of such an elastic system in these tissues provides, for the first time, a probable molecular basis for the elastic properties of this tissue. (C) 1997 W. B. Saunders Company Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:11:55