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Titolo:
Expression of vesicular monoamine transporters in endocrine hyperplasia and endocrine tumors of the oxyntic stomach
Autore:
Eissele, R; Anlauf, M; Schafer, MKH; Eiden, LE; Arnold, R; Weihe, E;
Indirizzi:
Univ Marburg, Dept Mol Neuroimmunol, Inst Anat & Cell Biol, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 Cell Biol, D-35033 Marburg, Germany Univ Marburg, Dept Gastroenterol & Endocrinol, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 ndocrinol, D-35033 Marburg, Germany NIMH, Mol Neurosci Sect, Lab Cellular & Mol Regulat, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 lar & Mol Regulat, NIH, Bethesda, MD 20892 USA
Titolo Testata:
DIGESTION
fascicolo: 5, volume: 60, anno: 1999,
pagine: 428 - 439
SICI:
0012-2823(199909/10)60:5<428:EOVMTI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZOLLINGER-ELLISON SYNDROME; GASTRIC CARCINOID-TUMORS; CELL HYPERPLASIA; RAT STOMACH; ECL CELLS; HISTAMINE TRANSPORTER; PERNICIOUS-ANEMIA; AMINE TRANSPORTER; NERVOUS-SYSTEM; ACHLORHYDRIA;
Keywords:
vesicular monoamine transporter; chronic atrophic gastritis; Zollinger-Ellison syndrome; gastric carcinoid; neuroendocrine carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Weihe, E Univ Marburg, Dept Mol Neuroimmunol, Inst Anat & Cell Biol, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 , D-35033 Marburg, Germany
Citazione:
R. Eissele et al., "Expression of vesicular monoamine transporters in endocrine hyperplasia and endocrine tumors of the oxyntic stomach", DIGESTION, 60(5), 1999, pp. 428-439

Abstract

Background: Gastric enterochromaffin-like (ECL) cells selectively express the vesicular monoamine transporter (VMAT) VMAT2, and enterochromaffin (EC)cells the VMAT1 isoform. Aims: We investigated whether VMAT isoform selection indicates the origin of endocrine hyperplasia and neoplasia from oxyntic ECL or EC cells and may be of prognostic significance in different types of gastric carcinoids. Methods: Tissue from patients with chronic atrophic gastritis (CAG), Zollinger-Ellison-syndrome (ZES), gastric carcinoids and neuroendocrine carcinoma (NEC) was investigated by immunohistology and in situ hybridization. Results: Endocrine cells forming diffuse, linear, and micronodular hyperplasia in CAG and ZES, as well as oxyntic microcarcinoids expressed both VMAT2 and chromogranin A (CgA) but neither VMAT1 nor serotonin. In five of six sporadic carcinoids VMAT2 and CgA but not VMAT1 were detected. One carcinoid was copositive for VMAT1 and serotonin but negative for VMAT2. Electron microscopy confirmed the VMAT2-positive tumors as ECLoma and the VMAT1 -immunoreactive carcinoid as EComa. Conclusions: VMAT2 and VMAT1 are reliable markers for differentiation of gastric endocrine hyperplasiaand neoplasia from ECL and EC cells, respectively. The significance of VMAT2 and VMAT1 as prognostic markers lies in the relatively poor prognosis for EComa compared to ECLoma, characterized by VMAT2 positivity. The absence of both VMAT2 and VMAT1 in NEC may indicate poor prognosis.

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Documento generato il 01/04/20 alle ore 09:53:22