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Titolo:
alpha/beta and gamma/delta TCR+ lymphocyte infiltration in necrotising choroidal melanomas
Autore:
Bialasiewicz, AA; Ma, JX; Richard, G;
Indirizzi:
Univ Hamburg, Augenklin Eppendorf, D-20251 Hamburg, Germany Univ Hamburg Hamburg Germany D-20251 Eppendorf, D-20251 Hamburg, Germany Hebei Med Univ, Eye Res Ctr, Shijiazhuang 050000, Peoples R China Hebei Med Univ Shijiazhuang Peoples R China 050000 0000, Peoples R China
Titolo Testata:
BRITISH JOURNAL OF OPHTHALMOLOGY
fascicolo: 9, volume: 83, anno: 1999,
pagine: 1069 - 1073
SICI:
0007-1161(199909)83:9<1069:AAGTLI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
UVEAL MALIGNANT-MELANOMA; PERIPHERAL-BLOOD; RECEPTOR REPERTOIRE; PROGNOSTIC FACTORS; TUMOR; CELLS; ENUCLEATION; ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bialasiewicz, AA Univ Hamburg, Augenklin Eppendorf, Martinistr 52, D-20251Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20251 rmany
Citazione:
A.A. Bialasiewicz et al., "alpha/beta and gamma/delta TCR+ lymphocyte infiltration in necrotising choroidal melanomas", BR J OPHTH, 83(9), 1999, pp. 1069-1073

Abstract

Aim-To detect specific tumour infiltrating T cells (TIL) carrying antigen specific MHC-I restricted receptor genes on necrotising and non-necrotisingmalignant melanomas and to correlate the findings with clinical data. Methods-alpha/beta- and gamma/delta- TIL were determined by immunohistochemical staining in melanomas of patients with known follow up of more than 10 years. An antigen retrieval method was used to determine variable genes 61 and gamma 1 on TCR+ cells by an anti-TCR V delta 1 and anti-Cr gamma M1, and of V alpha and V beta TCR+ by an anti-pan-TCR+ alpha/beta antibody. Results-Intratumoral TIL were present in 86 of 113 (76.1%) necrotising melanomas (NMM) v 21 of 100 (21%) in non-necrotising melanomas (MM); of these,V alpha/beta- TCR+ cells were present in 52 of 74 (70.3%) TIL harbouring NMM v four of 21 (19%) MM; V gamma 1 in 29 of 74 (39.2%) NMM v two of 21 (10%) MM; and V delta 1 in 39 of 74 (52.7%) NMM v three of 21 (14%) MM. Extratumoral lymphocytic infiltration was seen in 86 (76.1%) NMM including V alpha/beta TCR+ cells in 10 (11.6%) cases, v five (5%) MM cases with no V alpha/beta TCR+ cells detected. V gamma 1 and V delta 1 TCR+ cells were not found in extratumoral infiltrates. Conclusions-In NMM, the median survival was 69.3 (range 6-237) months, 19 of 74 patients (25.7%) survived 5 years, and mortality was associated with advanced stage (p<0.001), patient age (p<0.023), and extent of necrosis (p<0.048). Survival was increased with evidence of V gamma 1 and V delta 1 TCR cells (p<0.026).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:10:07