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Titolo:
Induction chemotherapy followed by concurrent standard radiotherapy and daily low dose cisplatin in locally advanced non-small-cell lung cancer
Autore:
Ardizzoni, A; Grossi, F; Scolaro, T; Giudici, S; Foppiano, F; Boni, L; Tixi, L; Cosso, M; Mereu, C; Ratto, GB; Vitale, V; Rosso, R;
Indirizzi:
Ist Nazl Ric Canc, Div Med Oncol 1, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 Med Oncol 1, I-16132 Genoa, Italy Ist Nazl Ric Canc, Div Radiat Oncol, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 Radiat Oncol, I-16132 Genoa, Italy Ist Nazl Ric Canc, Unit Clin Epidemiol & Trials, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 iol & Trials, I-16132 Genoa, Italy Ist Nazl Ric Canc, Serv Radiol, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 Serv Radiol, I-16132 Genoa, Italy Ctr Biotecnol Avanzate, I-16132 Genoa, Italy Ctr Biotecnol Avanzate Genoa Italy I-16132 vanzate, I-16132 Genoa, Italy Univ Genoa, Chair Thorac Surg, Genoa, Italy Univ Genoa Genoa ItalyUniv Genoa, Chair Thorac Surg, Genoa, Italy Univ Genoa, Ctr Resp Endoscopy, Genoa, Italy Univ Genoa Genoa ItalyUniv Genoa, Ctr Resp Endoscopy, Genoa, Italy
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 2, volume: 81, anno: 1999,
pagine: 310 - 315
SICI:
0007-0920(199909)81:2<310:ICFBCS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERAPY-ONCOLOGY-GROUP; RADIATION-THERAPY; CHEMORADIATION THERAPY; CLINICAL-TRIALS; PACLITAXEL; ETOPOSIDE;
Keywords:
induction chemotherapy; concurrent chemoradiation in NSCLC; phase II study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ardizzoni, A Ist Nazl Ric Canc, Div Med Oncol 1, Largo R Benzi 10, I-16132Genoa, Italy Ist Nazl Ric Canc Largo R Benzi 10 Genoa Italy I-16132 Italy
Citazione:
A. Ardizzoni et al., "Induction chemotherapy followed by concurrent standard radiotherapy and daily low dose cisplatin in locally advanced non-small-cell lung cancer", BR J CANC, 81(2), 1999, pp. 310-315

Abstract

Both induction chemotherapy and concurrent low-dose cisplatin have been shown to improve results of thoracic irradiation in the treatment of locally advanced non-small-cell lung cancer (NSCLC). This phase II study was designed to investigate activity and feasibility of a novel chemoradiation regimen consisting of induction chemotherapy followed by standard radiotherapy and concurrent daily low-dose cisplatin. Previously untreated patients with histologically/cytologically proven unresectable stage IIIA/B NSCLC were eligible. Induction chemotherapy consisted of vinblastine 5 mg m(-2) intravenously (i.v.) on days 1, 8, 15, 22 and 29, and cisplatin 100 mg m(-2) i.v. ondays 1 and 22 followed by continuous radiotherapy (60 Gy in 30 fractions) given concurrently with daily cisplatin at a dose of 5 mg m(-2) i.v. Thirty-two patients were enrolled. Major toxicity during induction chemotherapy was haematological: grade III-IV leukopenia was observed in 31% and grade IIanaemia in 16% of the patients. The most common severe toxicity during concurrent chemoradiation consisted of grade III leukopenia (21% of the patients); grade III oesophagitis occurred in only two patients and pulmonary toxicity in one patient who died of this complication. Eighteen of 32 patients(56%, 95% CI 38-73%) had a major response (11 partial response, seven complete response). With a median follow-up of 38.4 months, the median survivalwas 12.5 months and the actuarial survival rates at 1, 2 and 3 years were 52%, 26% and 19% respectively. The median event-free survival was 8.3 months with a probability of 40%, 23% and 20% at 1, 2 and 3 years respectively. Induction chemotherapy followed by concurrent daily low-dose cisplatin and thoracic irradiation, in patients with locally advanced NSCLC, is active and feasible with minimal non-haematological toxicity. Long-term survival results are promising and appear to be similar to those of more toxic chemoradiation regimens, warranting further testing of this novel chemoradiation strategy, (C) 1999 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:49:31