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Titolo:
Noradrenaline and mixed alpha(2)-adrenoceptor/imidazoline-receptor ligands: effects on sodium intake
Autore:
Sugawara, AM; Miguel, TT; de Oliveira, LB; Menani, JV; De Luca, LA;
Indirizzi:
Pualista State Univ, UNESP, Sch Dent, Dept Physiol Sci, BR-14801903 Araraquara, SP, Brazil Pualista State Univ Araraquara SP Brazil BR-14801903 BCaquara, SP, Brazil
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 839, anno: 1999,
pagine: 227 - 234
SICI:
0006-8993(19990828)839:2<227:NAMAL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED 3-PERCENT NACL; ALPHA-ADRENERGIC AGONISTS; WATER-INTAKE; RAT-BRAIN; BINDING-SITES; ALPHA-2-ADRENOCEPTORS; ALPHA(2)-ADRENOCEPTORS; CLONIDINE; SUBTYPES; INHIBITION;
Keywords:
adrenergic; imidazoline; sodium appetite; water intake; dehydration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: De Luca, LA Pualista State Univ, UNESP, Sch Dent, Dept Physiol Sci, Rua Humaita 1680, BR-14801903 Araraquara, SP, Brazil Pualista State Univ Rua Humaita 1680 Araraquara SP Brazil BR-14801903 BC
Citazione:
A.M. Sugawara et al., "Noradrenaline and mixed alpha(2)-adrenoceptor/imidazoline-receptor ligands: effects on sodium intake", BRAIN RES, 839(2), 1999, pp. 227-234

Abstract

The effect of noradrenaline, and mixed ligands to alpha(2)-adrenoceptors (alpha(2)-AR) and imidazoline receptors (IR), injected intracerebroventricularly (i.c.v.), on sodium intake of sodium depleted rats, was tested againstidazoxan, a mixed antagonist ligand to alpha(2)-AR and IR. The inhibition of sodium intake induced by noradrenaline (80 nmol) was completely reversedby idazoxan (160 and 320 nmol) injected i.c.v. The inhibition of sodium intake induced by mixed ligands to alpha(2)-AR and IR, UK14,304, guanabenz and moxonidine, was antagonized from 50 to 60% by idazoxan i.c.v. The resultsdemonstrate that noradrenaline, a non-ligand for IR, acts on alpha(2)-AR inhibiting sodium intake. The possibility that either alpha(2)-AR or IR mediate the effect of mixed agonists on sodium intake remains an open question. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:23:16