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Titolo:
Expression of nestin after traumatic brain injury in rat brain
Autore:
Kaya, SS; Mahmood, A; Li, Y; Yavuz, E; Chopp, M;
Indirizzi:
Henry Ford Hlth Sci Ctr, Dept Neurosurg, Detroit, MI 48202 USA Henry Ford Hlth Sci Ctr Detroit MI USA 48202 osurg, Detroit, MI 48202 USA Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI USA Henry Ford Hlth Sci Ctr Detroit MI USA Ctr, Dept Neurol, Detroit, MI USA Oakland Univ, Dept Phys, Rochester, MI USA Oakland Univ Rochester MI USAOakland Univ, Dept Phys, Rochester, MI USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 840, anno: 1999,
pagine: 153 - 157
SICI:
0006-8993(19990904)840:1-2<153:EONATB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RADIAL GLIA; ASTROCYTES; CELLS; CNS; CORTEX;
Keywords:
nestin; traumatic brain injury; astrocyte; microglia; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Mahmood, A Henry Ford Hlth Sci Ctr, Dept Neurosurg, 2799 W Grand Blvd, Detroit, MI 48202 USA Henry Ford Hlth Sci Ctr 2799 W Grand Blvd Detroit MI USA48202
Citazione:
S.S. Kaya et al., "Expression of nestin after traumatic brain injury in rat brain", BRAIN RES, 840(1-2), 1999, pp. 153-157

Abstract

We tested the hypothesis that traumatic brain injury upregulates expression of nestin, an embryonic cell intermediate filament protein. Brain from rats (n = 24) subjected to controlled cortical impact injury and sham operated (n = 3) and normal(n = 3) rats were processed for dual label immunohistochemical study to identify cellular expression of nestin. Our results show that in normal noninjured animals, nestin is expressed slightly and localized only in a few endothelial and subventricular cells. In contrast, at 1-4 weeks postinjury nestin is strongly expressed in astrocytes and microglia. The expression of nestin in astrocytes and microglia after traumatic brain injury support the hypothesis that injured cerebral tissue expresses developmental proteins, and that these proteins may promote recovery after injury. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 10/07/20 alle ore 09:48:53