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Titolo:
The differential impact of training stress and final examination stress onherpesvirus latency at the United States Military Academy at West Point
Autore:
Glaser, R; Friedman, SB; Smyth, J; Ader, R; Bijur, P; Brunell, P; Cohen, N; Krilov, LR; Lifrak, ST; Stone, A; Toffler, P;
Indirizzi:
Ohio State Univ, Med Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH43210 USA Ohio State Univ Columbus OH USA 43210 & Med Genet, Columbus, OH43210 USA Montefiore Med Ctr, Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467USA Montefiore Med Ctr Bronx NY USA 10467 ed, Dept Pediat, Bronx, NY 10467USA SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA Univ Rochester, Sch Med, Dept Psychiat, Rochester, NY 14627 USA Univ Rochester Rochester NY USA 14627 t Psychiat, Rochester, NY 14627 USA Montefiore Med Ctr, Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467USA Montefiore Med Ctr Bronx NY USA 10467 ed, Dept Pediat, Bronx, NY 10467USA Cedars Sinai Med Ctr, Dept Pediat, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Univ Rochester, Sch Med, Dept Microbiol & Immunol, Rochester, NY 14627 USAUniv Rochester Rochester NY USA 14627 & Immunol, Rochester, NY 14627 USA N Shore Univ Hosp, Dept Pediat, Manhasset, NY 11030 USA N Shore Univ HospManhasset NY USA 11030 Pediat, Manhasset, NY 11030 USA US Mil Acad, W Point, NY 10996 USA US Mil Acad W Point NY USA 10996US Mil Acad, W Point, NY 10996 USA
Titolo Testata:
BRAIN BEHAVIOR AND IMMUNITY
fascicolo: 3, volume: 13, anno: 1999,
pagine: 240 - 251
SICI:
0889-1591(199909)13:3<240:TDIOTS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; VIRAL CAPSID ANTIGEN; SIMPLEX VIRUS; MEDICAL-STUDENTS; IMMUNE-RESPONSE; MODULATION; INFECTION; REACTIVATION; PERSONALITY; INTERFERON;
Keywords:
Epstein-Barr virus (EBV); herpes simplex virus type-1 (HSV-1); human herpesvirus 6; stress; West Point cadets; psychoneuroimmunology virus latency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Glaser, R Ohio State Univ, Med Ctr, Dept Mol Virol Immunol & Med Genet, Columbus, OH43210 USA Ohio State Univ Columbus OH USA 43210 et, Columbus, OH43210 USA
Citazione:
R. Glaser et al., "The differential impact of training stress and final examination stress onherpesvirus latency at the United States Military Academy at West Point", BRAIN BEH, 13(3), 1999, pp. 240-251

Abstract

In this study, we searched for evidence for reactivation of three latent herpesviruses, Epstein-Barr virus (EBV), herpes simplex virus type-1 (HSV-1), and human herpesvirus 6 (HHV-6), in West Point cadets experiencing two different stressors. Blood samples were obtained from cadets before and aftera 6-week training period known as "Cadet Basic Training" (CBT), at a baseline prior to final examinations, and then once again during the week of final examinations. Antibody titers to latent HSV-1, EBV, and HHV-6 were determined as a measure of the steady-state expression of latent virus. EBV virus capsid antigen (VCA) IgG antibody titers were unchanged in blood samples obtained prior to and immediately after CBT. However, EBV antibody titers were significantly higher in the blood sample obtained during examination week than in the baseline period before examination; they were also higher than antibody titers before/after CBT. None of the serum samples were positive for EBV VCA IgM antibodies, indicating that the changes in antibody titers to EBV were not associated with recent EBV infections in the class. No significant changes in antibody titers to HSV-1 or HSV-6 were found over the identical time periods, including examination week. Academic stress but notCBT modulated the steady-state expression of latent EBV, resulting in the reactivation of latent virus. The same stressors, however, did not affect the steady-state expression of latent HSV-1 or HSV-6, at least as measured by changes in antibody titers. The data provide additional evidence of the impact of different psychological stressors on the steady-state expression of latent herpesviruses. (C) 1999 Academic Press.

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Documento generato il 23/01/21 alle ore 03:44:04