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Titolo:
A high-density differential screening strategy for identification of foveagenes with altered expression in the retina during aging
Autore:
Somiari, RI; Wong, P; Bernstein, SL;
Indirizzi:
Univ Maryland, Dept Ophthalmol, Lab Mol Res, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Lab Mol Res, Baltimore, MD 21201 USA Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada Univ Alberta Edmonton AB Canada T6G 2E9 Sci, Edmonton, AB T6G 2E9, Canada
Titolo Testata:
BIOTECHNOLOGY TECHNIQUES
fascicolo: 9, volume: 13, anno: 1999,
pagine: 577 - 581
SICI:
0951-208X(199909)13:9<577:AHDSSF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Keywords:
aging; fovea array; retinal genes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Somiari, RI Univ Maryland, Dept Ophthalmol, Lab Mol Res, 10 S Pine St,MSTF5-65, Baltimore, MD 21201 USA Univ Maryland 10 S Pine St,MSTF 5-65 Baltimore MD USA 21201 SA
Citazione:
R.I. Somiari et al., "A high-density differential screening strategy for identification of foveagenes with altered expression in the retina during aging", BIOTECH TEC, 13(9), 1999, pp. 577-581

Abstract

A human fovea cDNA library was arrayed at high-density and reacted with age-specific (4 yr & 80 yr) retinal probes to identify genes with altered expression during aging. Using this approach, we screened 55,368 genes by Southern analysis and determined that similar to 0.7% are differentially expressed in young and old tissues. Northern analysis of total RNA from retina ofhumans aged 2-94 yr show that expression of one of the clones identified (clone dd(112)) decreases with aging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 21:56:20