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Titolo:
The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes
Autore:
Bruyns, C; Pesesse, X; Moreau, C; Blero, D; Erneux, C;
Indirizzi:
Free Univ Brussels, Interdisciplinary Res Inst, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 nst, B-1070 Brussels, Belgium
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 7-8, volume: 380, anno: 1999,
pagine: 969 - 974
SICI:
1431-6730(199907/08)380:7-8<969:TTSI5S>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE; FC-GAMMA-RIIB; PHOSPHATASE SHIP; CELL ACTIVATION; RECEPTOR; 1,3,4,5-TETRAKISPHOSPHATE; PROTEIN; SHC; PATHWAY; CTLA-4;
Keywords:
phosphatidylinositol metabolism; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Erneux, C Free Univ Brussels, Interdisciplinary Res Inst, Campus Erasme,808 Route Lennik, B-1070 Brussels, Belgium Free Univ Brussels Campus Erasme,808 Route Lennik Brussels Belgium B-1070
Citazione:
C. Bruyns et al., "The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes", BIOL CHEM, 380(7-8), 1999, pp. 969-974

Abstract

The activation of many hematopoietic cells via cytokine receptors, as wellas B and T cell receptors, leads to the tyrosine phosphorylation of Shc and its association with both Grb2-Sos1 complexes and with a 145 kDa protein referred to as the SH2 containing inositol 5-phosphatase (SHIP1). In a search of putative 5-phosphatase isoenzymes, we have isolated a second SH2 domain containing inositol 5-phosphatase, referred to as (SHIP2). Both SHIP1 and SHIPS are coexpressed in human T lymphocytes. This was shown at the protein level by Western blot analysis in transformed T cell lines and in peripheral blood T lymphocytes either unstimulated or after in vitro activation through TCR-CD3 complex. SHIP1 protein level was not modulated after activation of T lymphocytes, in contrast to SHIP2, which was increased after longterm stimulation. SHIP1 was tyrosine phosphorylated in resting naive T cells. This was not observed in the transformed T cell lines. T lymphocyte is therefore a model of coexpression of the two SHP-containing inositol 5-phosphatases SHIP1 and SHIP2.

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Documento generato il 12/07/20 alle ore 06:41:24