Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
p53 is a rate-limiting factor in the repair of higher-order DNA structure
Autore:
Aranda-Anzaldo, A; Orozco-Velasco, F; Garcia-Villa, E; Gariglio, P;
Indirizzi:
Inst Politecn Nacl, CINVESTAV, Dept Genet & Biol Mol, Mexico City 07000, DF, Mexico Inst Politecn Nacl Mexico City DF Mexico 07000 ico City 07000, DF, Mexico UAEM, Fac Med, Mol Biol Lab, Mexico City 50000, DF, Mexico UAEM Mexico City DF Mexico 50000 Biol Lab, Mexico City 50000, DF, Mexico IPN, CICATA, Mexico City 11500, DF, Mexico IPN Mexico City DF Mexico 11500 PN, CICATA, Mexico City 11500, DF, Mexico
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
fascicolo: 3, volume: 1446, anno: 1999,
pagine: 181 - 192
SICI:
0167-4781(19990903)1446:3<181:PIARFI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMPLEX VIRUS TYPE-1; NUCLEOTIDE EXCISION-REPAIR; HOMOLOGOUS RECOMBINATION; TUMOR-SUPPRESSOR; HUMAN FIBROBLASTS; NUCLEAR MATRIX; CELLS; UV; TRANSCRIPTION; REPLICATION;
Keywords:
DNA loop; DNA repair; DNA topology; nuclear matrix; p53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Gariglio, P Inst Politecn Nacl, CINVESTAV, Dept Genet & Biol Mol, Apdo Postal 14-740, Mexico City 07000, DF, Mexico Inst Politecn Nacl Apdo Postal 14-740 Mexico City DF Mexico 07000
Citazione:
A. Aranda-Anzaldo et al., "p53 is a rate-limiting factor in the repair of higher-order DNA structure", BBA-GENE ST, 1446(3), 1999, pp. 181-192

Abstract

The product of the p53 tumor suppressor gene has been implicated in safeguarding genomic stability by transactivating genes involved in cell cycle arrest, repair of DNA damage or induction of apoptosis. Several properties ofp53 suggest that it might be directly involved in DNA repair processes. Eukaryotic DNA is highly organized in supercoiled loops anchored to the nuclear matrix. This organization is very important for cell function and survival, suggesting that repair of DNA damage must include both, the integrity of the double helix and the complex DNA topology. In this work, we studied the kinetics and efficiency of higher-order DNA structure repair in cells with normal and reduced levels of p53, and present evidence suggesting that p53 may be involved in the stabilization and/or repair of higher-order DNA structure. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 04:24:36