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Titolo:
Anxiety in a transgenic mouse model of cortical-limbic neuropotentiated compulsive behavior
Autore:
McGrath, MJ; Campbell, KM; Veldman, MB; Burton, FH;
Indirizzi:
Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 5, volume: 10, anno: 1999,
pagine: 435 - 443
SICI:
0955-8810(199909)10:5<435:AIATMM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; D1 DOPAMINE RECEPTOR; OPEN-FIELD TEST; RAT-BRAIN; CORTEX; LOCALIZATION; STIMULATION; DISORDER; AMYGDALA; NEURONS;
Keywords:
transgenic mouse; cholera toxin; dopamine D1 receptor; intercalated nucleus; amygdala; leaping; biting; perseverance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Burton, FH Univ Minnesota, Dept Pharmacol, 3-249 Millard Hall,435 DelawareSt SE, Minneapolis, MN 55455 USA Univ Minnesota 3-249 Millard Hall,435 Delaware St SE Minneapolis MN USA 55455
Citazione:
M.J. McGrath et al., "Anxiety in a transgenic mouse model of cortical-limbic neuropotentiated compulsive behavior", BEHAV PHARM, 10(5), 1999, pp. 435-443

Abstract

Anxiety and amygdalar stimulation may induce or exacerbate compulsions triggered by cortical-limbic hyperactivity, as in human obsessive-compulsive disorder (OCD). We previously created transgenic mice that exhibit OCD-like biting, movement and behavioral perseverance abnormalities. These behaviorsare caused by expression of a neuropotentiating cholera toxin (CT) transgene in dopamine D1 receptor-expressing (D1+) neurons within the amygdalar intercalated nucleus (ICN) and within cortical areas that project to orbitofrontal cortex and striatum. Here we tested whether anxiety and increased amygdalar stimulation may play a role in eliciting or exacerbating such behaviors. D1CT mice exhibited increased thigmotaxis (tendency of mite to remain along the perimeter of open areas) in the open field assay, and increased latency to first transit and reduced transit number in the light-dark assay. These studies indicate that the D1CT mice exhibit a significant increase in behavioral indicators of anxiety. Furthermore, yohimbine, a drug that induces both amygdalar stimulation and behavioral indicators of anxiety, exacerbated abnormal leaping in D1CT mice but failed to exacerbate their abnormal behavioral perseverance. These data suggest that chronic potentiation of D1+ neurons in the amygdalar ICN increases anxiety and facilitates particular compulsive behaviors. (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 29/03/20 alle ore 09:29:57